Lower respiratory viral illnesses: improved diagnosis by molecular methods and clinical impact

American Journal of Respiratory and Critical Care Medicine
Jorge GarbinoLaurent Kaiser

Abstract

We assessed the frequency and the potential role of respiratory viruses on disease outcomes in hospitalized patients and lung transplant recipients who underwent a bronchoalveolar lavage (BAL) for an acute respiratory infection. BAL specimens (148) were analyzed by reverse transcription-polymerase chain reaction for the presence of 11 different viruses, as well as Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. Respiratory viruses were identified in 34 of 117 BAL specimens (29%) obtained in patients with a suspected respiratory infection and in only 2 of 31 control subjects (7%) (p < 0.01). M. pneumoniae was identified in five additional cases. Only 30% of cases that were virus positive by molecular methods were also positive by cell culture analysis. Rhinovirus was the most frequently identified virus (56% of cases) followed by respiratory syncytial virus (27%). In lung transplant recipients, the rate of viral infections was 55% in cases with respiratory symptoms compared with only 4% in control subjects (p < 0.001). In these cases, respiratory viral infections were associated with significant lung function abnormalities. By using reverse transcription-polymerase chain reaction assays, we frequentl...Continue Reading

References

Oct 15, 1995·Annals of Internal Medicine·T G WaldS Gravenstein
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
May 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E WhimbeyG P Bodey
Sep 1, 1996·Archives of Pediatrics & Adolescent Medicine·A G Randolph, E E Wang
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·S L JohnstonS T Holgate
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M YousufE Whimbey
Sep 15, 1999·Lancet·E A Simoes
Oct 26, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S GhoshE Whimbey
Dec 30, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L KaiserF G Hayden
Jun 6, 2000·The Journal of Infectious Diseases·N G PapadopoulosS L Johnston
Mar 20, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E MalcolmL Kaiser
Jun 23, 2001·The New England Journal of Medicine·C B Hall
May 10, 2002·The Journal of Infectious Diseases·Ann R FalseyFrederick G Hayden
Feb 25, 2003·The Journal of Infectious Diseases·Ann R FalseyEdward E Walsh
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Astrid VabretFrançois Freymuth
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael G IsonMichael Boeckh
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·J GarbinoD Lew
Jun 5, 2003·Emerging Infectious Diseases·Guy BoivinPierre Déry
Nov 19, 2003·The Journal of Infectious Diseases·Bernadette G van den HoogenRon A M Fouchier
Dec 20, 2003·Lancet·Thomas M File
Jan 13, 2004·Reviews in Medical Virology·Frederick G Hayden
Jan 30, 2004·The New England Journal of Medicine·John V WilliamsJames E Crowe
Feb 26, 2004·Paediatric Respiratory Reviews·Nikolaos G Papadopoulos
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Apr 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ron A M FouchierAlbert D M E Osterhaus
May 8, 2004·American Journal of Respiratory and Critical Care Medicine·Anthony P KhalifahMichael J Walter
Jul 10, 2004·Journal of Clinical Microbiology·Christelle DeffernezLaurent Kaiser
Jul 31, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Janet T LeeSara J Shumway

❮ Previous
Next ❯

Citations

Jun 23, 2006·Intensive Care Medicine·Robert J CameronPeter J Rye
Dec 15, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S JouneauB Desrues
Apr 1, 2010·Seminars in Respiratory and Critical Care Medicine·Pali Dedhiya Shah, John F McDyer
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vincenzo PuroMaria R Capobianchi
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jorge GarbinoLaurent Kaiser
Nov 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent Kaiser
Nov 12, 2005·The Pediatric Infectious Disease Journal·Laurent KaiserUrs Frey
Jan 30, 2007·The Pediatric Infectious Disease Journal·Nicolas RegameyUNKNOWN Swiss Paediatric Respiratory Research Group
Apr 9, 2005·Current Opinion in Pulmonary Medicine·Ana RañóAntoni Torres
Nov 4, 2008·The Pediatric Infectious Disease Journal·Tuomas JarttiOlli Ruuskanen
Jun 22, 2012·Journal of Clinical Microbiology·Manuel SchiblerCaroline Tapparel
Sep 30, 2006·American Journal of Respiratory and Critical Care Medicine·Laurent KaiserPaola M Soccal
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·Stephen B Greenberg
May 5, 2007·Virology Journal·Amy L KistlerJoseph L DeRisi
Oct 7, 2006·Critical Care : the Official Journal of the Critical Care Forum·Cédric DaubinPierre Charbonneau
Feb 23, 2010·PloS One·Antoine NougairèdeXavier de Lamballerie
May 31, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Sue HammondJoan E Durbin
May 1, 2009·Emerging Infectious Diseases·Caroline TapparelLaurent Kaiser
Feb 26, 2014·Virology Journal·Julie DelangueXavier de Lamballerie
Feb 25, 2009·European Journal of Pediatrics·Manon Cevey-MacherelMario Gehri
Feb 3, 2007·Expert Review of Anti-infective Therapy·Guy Vernet
Aug 1, 2008·Expert Opinion on Medical Diagnostics·Katia Jaton-Ogay, Jacques Bille
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Deepali KumarAtul Humar
Feb 23, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P R A MeylanL Kaiser
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Allan R GlanvilleMonique A Malouf
Jul 27, 2012·Scandinavian Journal of Infectious Diseases·Jean-Michel MansuyJacques Izopet
May 4, 2010·Chest·Omar KheradOlivier T Rutschmann
Mar 1, 2014·Korean journal of pediatrics·Woo Kyung Kim
May 2, 2012·Allergy, Asthma & Immunology Research·Woo Kyung Kim, James E Gern
Aug 22, 2018·European Clinical Respiratory Journal·Nada TownsiShannon J Simpson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Michael G IsonMichael Boeckh
The Journal of Infectious Diseases
Nikolaos G PapadopoulosS L Johnston
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Vincenzo PuroMaria R Capobianchi
© 2021 Meta ULC. All rights reserved