Lower serum concentration of matrix metalloproteinase-3 in the acute stage of myocardial infarction

Journal of Internal Medicine
A SamnegårdPer Eriksson

Abstract

The importance of matrix metalloproteinases (MMPs) in the progression and rupture of the atherosclerotic plaque is gaining increasing recognition but the mechanisms are not yet fully understood. The aim of this study was to investigate the significance of MMP-3 in the acute phase of myocardial infarction (MI) and the influence of the -1612 5A/6A MMP-3 gene promoter polymorphism on serum MMP-3 concentration. One-hundred and sixty-four patients admitted with ST-elevation MI and receiving thrombolysis treatment were included in this study. Serum MMP-3 was analysed at admission, after 48 h and at 3 months. Serum MMP-3 concentration was significantly increased at 3 months when compared with admission and 48 h (19.5 ng mL(-1) [14.4-24.7] vs. 15.5 ng mL(-1) [10.5-21.8] at admission, P < 0.001; and 14.7 ng mL(-1) [9.9-23.8] at 48 h, P < 0.001). Furthermore, we found the -1612 5A/6A polymorphism to influence the serum concentration of MMP-3 at all time-points: 14.1 ng mL(-1) [10.2-18.8] in 5A/5A; 19.6 ng mL(-1) [15.0-24.4] in 5A/6A; and 24.0 ng mL(-1) [20.1-32.3] in 6A/6A genotype at 3 months (P < 0.001 between all groups). Female patients had lower serum MMP-3 concentration than male patients at all time-points (14.8 ng mL(-1) [9.4-20....Continue Reading

References

Jan 1, 1973·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·K Carlson
Aug 1, 1996·European Heart Journal·K Schenck-Gustafsson
Aug 15, 1998·Science·M RonaghiP Nyrén
Dec 2, 1998·Basic Research in Cardiology·S R Maxwell
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Apr 13, 2000·Journal of Internal Medicine·P Libby
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A GnassoC Cortese
Jul 4, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·Y NojiH Mabuchi
Sep 15, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J SilenceH R Lijnen
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
Dec 17, 2003·The American Journal of Cardiology·Teruo InoueNobuo Yoshimoto
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Philip R Brauer
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason L JohnsonChristopher L Jackson

❮ Previous
Next ❯

Citations

Dec 29, 2010·Clinical Reviews in Allergy & Immunology·P Roux-LombardN Vuilleumier
Jul 21, 2009·Cephalalgia : an International Journal of Headache·M AshinaJ Olesen
Sep 1, 2015·The International Journal of Neuroscience·Xiao-Ya HuangZu-Sen Ye
Mar 17, 2010·Progress in Cardiovascular Diseases·Magnus BäckStefan Agewall
Oct 19, 2007·Journal of the Neurological Sciences·Tamara DjurićDragan Alavantić
May 10, 2008·Cardiovascular Therapeutics·Nina KaludercicNazareno Paolocci
Jul 18, 2016·Journal of the Neurological Sciences·Rui WangZhen Hong
Feb 1, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura E Crotty AlexanderEllen C Breen
Sep 1, 2006·Journal of Clinical Neurology·Hahn Young Kim, Seol-Heui Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.