Lower-Sized Chitosan Nanocapsules for Transcutaneous Antigen Delivery

Nanomaterials
Juan I BussioJose V Gonzalez-Aramundiz

Abstract

Transcutaneous vaccination has several advantages including having a noninvasive route and needle-free administration; nonetheless developing an effective transdermal formulation has not been an easy task because skin physiology, particularly the stratum corneum, does not allow antigen penetration. Size is a crucial parameter for successful active molecule administration through the skin. Here we report a new core-shell structure rationally developed for transcutaneous antigen delivery. The resulting multifunctional carrier has an oily core with immune adjuvant properties and a polymeric corona made of chitosan. This system has a size of around 100 nm and a positive zeta potential. The new formulation is stable in storage and physiological conditions. Ovalbumin (OVA) was used as the antigen model and the developed nanocapsules show high association efficiency (75%). Chitosan nanocapsules have high interaction with the immune system which was demonstrated by complement activation and also did not affect cell viability in the macrophage cell line. Finally, ex vivo studies using a pig skin model show that OVA associated to the chitosan nanocapsules developed in this study penetrated and were retained better than OVA in solution. T...Continue Reading

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Citations

Nov 21, 2018·Pharmaceutical Development and Technology·M Javiera Alvarez-FigueroaJosé Vicente González-Aramundiz
Feb 8, 2019·Therapeutic Delivery·Carlos GamazoRyan F Donnelly
May 28, 2019·Pharmaceutics·Juan I BussioJosé Vicente González-Aramundiz
Sep 24, 2020·Biomedicines·A Katharina KolonkoWolf-Michael Weber
Sep 19, 2020·Pharmaceutical Research·María Javiera Alvarez-FigueroaJosé Vicente González-Aramundiz
Aug 7, 2019·International Journal of Pharmaceutics·Genada SinaniErdal Cevher
Oct 31, 2018·Molecular Pharmaceutics·José Vicente González-AramundizNoemi Stefánia Csaba

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Methods Mentioned

BETA
Dynamic Light Scattering
Scanning Transmission Electron Microscopy
ELISA
electrophoresis

Software Mentioned

ImageLab
Expert
Design

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