Lower skeletal muscle capillarization in hypertensive elderly men

Experimental Gerontology
Marine GueugneauDaniel Béchet

Abstract

Aging strongly affects the skeletal muscle and is associated with microvascular dysfunctions. Age is also a primary risk factor for the metabolic syndrome, which is a cluster of metabolic and cardiovascular symptoms. Among the metabolic syndrome components, hypertension is the most prevalent in elderly subjects and has a central role in vascular alterations. Despite critical clinical outcomes, the effects of hypertension and metabolic syndrome on skeletal muscle capillarization have poorly been investigated during aging. In the present study, muscle biopsies from normotensive young (YO) and elderly (ELc) men, and elderly men with hypertension (EL-HT) or metabolic syndrome (EL-MS) were assessed for the number of capillaries around a fiber (CAF), capillary-to-fiber perimeter exchange (CFPE), length of contact to perimeter of fiber ratio (LC/PF), capillary tortuosity, and for extracellular matrix (ECM) embedding capillaries. As capillarization and muscle mitochondrial oxidative capacity may be associated, we also investigated cytochrome c oxidase (COX) content. Our findings indicate that capillarization and COX did not change between normotensive adult and old individuals. They further reveal that hypertension in elderly men is as...Continue Reading

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Citations

Aug 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Céline DalleCécile Gladine
Jun 20, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David MonteroCarsten Lundby
Jun 4, 2020·International Journal of Molecular Sciences·Emiliana GiacomelloLuana Toniolo
May 1, 2021·International Journal of Molecular Sciences·Marine GueugneauDaniel Béchet
Aug 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giorgio VarescoVianney Rozand

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