Lower Thalamic Blood Flow Is Associated With Slower Stride Velocity in Older Adults

Frontiers in Aging Neuroscience
Noah D KoblinskyAndrew D Robertson

Abstract

Gait deficits are associated with brain atrophy and white matter hyperintensities (WMH) - both markers of underlying cerebral small vessel disease (SVD). Given reduced subcortical cerebral blood flow (CBF) is prevalent in SVD, we tested the hypothesis that regional CBF is positively associated with gait performance among older adults. Thirty-two older adults (55-80 years) with at least one vascular risk factor were recruited. We assessed gait during 2 consecutive walking sequences using a GAITRite system: (1) at a self-selected pace, and (2) while performing a serial subtraction dual-task challenge. We quantified CBF using pseudo-continuous arterial spin labeling MRI within 4 regions of interest: putamen, pallidum, thalamus, and hippocampus. We investigated associations between gait characteristics and overall CBF adjusting for age, sex, and height in an omnibus approach using multivariate analysis of variance, followed by regression analysis with each individual region. We also conducted further regression analyses to investigate associations between gait characteristics and frontal lobe CBF. Sensitivity analyses examined how the observed associations were modified by WMH, executive function, and depressive symptoms. A change ...Continue Reading

References

Aug 3, 2000·Journal of Clinical and Experimental Neuropsychology·K Arbuthnott, J Frank
Apr 18, 2002·Neurobiology of Aging·Kenneth G Pugh, Lewis A Lipsitz
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Oct 4, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Auke P A AppelmanUNKNOWN SMART Study Group
Dec 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Galit Yogev-SeligmannNir Giladi
Jul 11, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jeremy D Schmahmann, Deepak N Pandya
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Velandai SrikanthDavid Reutens
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marianne B van IerselMarcel G M Olde Rikkert
Jan 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Caterina RosanoAnne B Newman
Mar 11, 2009·Brain Research·Katja BertschEwald Naumann
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Erin GibsonNancy J Lobaugh
Jun 26, 2010·Stroke; a Journal of Cerebral Circulation·Karlijn F de LaatFrank-Erik de Leeuw
Jan 6, 2011·JAMA : the Journal of the American Medical Association·Stephanie StudenskiJack Guralnik
Jun 16, 2011·Annals of Neurology·Farzaneh A SorondLewis A Lipsitz
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci
Feb 1, 2012·Archives of Physical Medicine and Rehabilitation·Manuel Montero-OdassoMark Speechley
Mar 1, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joel AanerudAlbert Gjedde
Dec 20, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle M MielkeRonald C Petersen
May 21, 2013·Aging & Mental Health·Daniel Paulson, Peter A Lichtenberg
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
Aug 28, 2014·Journal of Alzheimer's Disease : JAD·Christina E WierengaZvinka Z Zlatar
Dec 3, 2014·Experimental Gerontology·Olivier BeauchetGilles Allali
Jul 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hazel I ZonneveldMeike W Vernooij
Oct 22, 2015·Journal of Cognitive Neuroscience·Brad ManorAlvaro Pascual-Leone
Sep 23, 2016·MMWR. Morbidity and Mortality Weekly Report·Gwen BergenElizabeth R Burns
Jan 27, 2017·Journal of Movement Disorders·Kaoru Takakusaki
Apr 28, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Azizah J Jor'danLewis A Lipsitz
Jul 7, 2017·Journal of Magnetic Resonance Imaging : JMRI·Zahra ShirzadiBradley J MacIntosh
Nov 14, 2017·Journal of the American Geriatrics Society·Ali EzzatiCarol A Derby
Apr 3, 2018·Journal of the American Geriatrics Society·Manuel Montero-OdassoUNKNOWN Canadian Gait and Cognition Network
May 29, 2018·Nature Reviews. Neurology·Annemieke Ter TelgteFrank-Erik de Leeuw

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