Lower Urinary Tract Symptoms in Subjects with Subclinical Cerebral White Matter Lesions

Journal of Aging Research
Chi-Hang YeeChi-Fai Ng

Abstract

We assessed the impact of cerebral white matter lesions (WMLs) on lower urinary tract symptoms in subjects with normal neurological and cognitive function. A cohort of community-dwelling subjects aged ≥65 years were recruited to undergo MRI brain assessment. WMLs were graded using the Fazekas scale from 0 to 3. A separate telephone interview was carried out to assess the urinary symptoms in these subjects using the questionnaire Overactive Bladder-Validated 8-Question Awareness Tool (OAB-V8). 800 community-dwelling elderly subjects were recruited to undergo MRI brain. In this cohort, 431 subjects responded to the telephone interview concerning their urinary symptoms. Among the respondents, 21.1% did not exhibit any WML on their MRI brain. Most of the subjects (52.6%) exhibited grade 1 WML. On logistic regression, age was found to be positively correlated with the Fazekas score (correlation coefficient 0.203, p ≤ 0.01). Using a cutoff of 8 on OAB-V8, 22% of the respondents experienced OAB. Presence of WML, hypertension, or diabetes mellitus was not found to be correlated with storage urinary symptoms or OAB-V8 total score. Multiple logistic regression analysis did not show the presence of WML to be associated with the diagnosis ...Continue Reading

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Citations

Nov 5, 2019·Current Bladder Dysfunction Reports·Rose Khavari, Timothy B Boone
Oct 30, 2020·Chinese Medical Journal·Una ClancyJoanna M Wardlaw
Jan 8, 2021·Chinese Medical Journal·Alexander Yuk Lun LauVincent Chung Tong Mok

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