May 20, 1999

Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

Psychiatry Research
M MaesH Y Meltzer

Abstract

Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester compositions of individual saturated fatty acids (SFAs), monounsaturated FAs (MUFAs) and polyunsaturated FAs (PUFAs) in major depressed patients vs. healthy volunteers; (ii) the relationships between the above FAs and lowered serum zinc (Zn), a marker of the inflammatory response in depression; and (iii) the effects of subchronic treatment with antidepressants on FAs in depression. The composition of the FAs was determined by means of thin layer chromatography in conjunction with gas chromatography. Lipid concentrations were assayed by enzymatic colorimetric methods. The oxidative potential index (OPI) of FAs was computed in 34 major depressed inpatients and 14 normal volunteers. Major depression was associated with: increased MUFA and C22:5omega3 proportions and increased C20:4omega6/C20:5omega3 and C22:5omega6/C22:6omega3 ratios; lower C22:4omega6, C20:5omega3 and C22:5omega3 fractions in phospholipids; lower C18:3omega...Continue Reading

Mentioned in this Paper

Metabolic Process, Cellular
Systemic Inflammatory Response Syndrome
Involutional Paraphrenia
Depressed - Symptom
Inflammation Mediators
Omega-3 Fatty Acids
Chromatography, Qualitative; Thin Layer, Analyte Not Elsewhere Specified
Fatty Acids, Monounsaturated
Dietary Requirements
Saturated Fat

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