Dec 30, 1999

Lowered yields of virus-induced interferon production in leukocyte cultures and risk of recurrent respiratory infections in children

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Anne PitkärantaT Hovi

Abstract

To study the correlation between the yield of virus-induced interferon (IFN) production in leukocyte cultures and the risk of recurrent respiratory infections. A sample of 71 consecutive children enrolled in the Finnish Otitis Media Cohort Study were selected. Children suffering from frequently recurring respiratory infections (FRRIs) were defined as the highest quintile of the entire cohort of 329 children, as regards the number of upper respiratory infections (URIs) and/or episodes of acute otitis media (AOM) during the follow-up period from 2 to 24 months. In the sample of 71 children, there were 18 children with FRRI (> or = 9 URI and/or > or = 4 AOM). Leukocyte cultures, prepared from blood drawn from these 18 children at 6 months of age, produced lower yields of IFN than those of the remaining 53 children, when stimulated with adenovirus (P <0.001), coronavirus (P<0.001) or rhinovirus (P=0.002). The difference in IFN yields was even greater (P<0.001 with all three viruses) if the comparison was made between children with FRRI and those with no or maximally one URI during the follow-up period. When the IFN production capacity induced by rhinovirus was measured at the age of 24 months, a statistically significant difference...Continue Reading

Mentioned in this Paper

Interferon Production
Urised
Influenza
Genus: Coronavirus
Human leukocyte interferon
Coronavirus, Rabbit
Interferon
Leukocytes
Influenza A virus
Respiratory Tract Infections

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