Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats

Journal of Clinical Biochemistry and Nutrition
Keiko AzumaJunji Terao

Abstract

The protective effect of onion against oxidative stress in streptozotosin-induced diabetic rats was investigated in comparison with that of quercetin aglycone. We measured oxidative stress biomarkers involving the susceptibility of the plasma against copper ion-induced lipid peroxidation, which was estimated by the amounts of thiobarbituric acid-reactive substances (TBARS) and cholesteryl ester hydroperoxides, and urine TBARS and 8-hydroxydeoxyguanosine contents. After the 12-week feeding period, plasma glucose levels and these biomarkers increased in diabetic rats compared to normal rats. In diabetic rats fed a 6.0% onion diet (quercetin equivalent: 0.023%), quercetin metabolites accumulated in the plasma at concentrations of approximately 35 microM. Onion intake decreased plasma glucose levels and lowered the oxidative stress biomarkers. On the other hand, quercetin metabolites in the plasma of rats fed a diet with 0.023% quercetin aglycone were found at lower concentrations (14.2 microM) than the rats fed the onion diet. Furthermore, oxidative stress biomarkers were higher in the quercetin diet group compared to the onion diet group. These results strongly suggest that onion intake suppresses diabetes-induced oxidative stres...Continue Reading

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Citations

Jan 28, 2010·Journal of Clinical Biochemistry and Nutrition·Satoko AkiyamaMariko Uehara
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Razieh JalalMorteza Behnam Rasuli
Mar 10, 2009·Bioscience, Biotechnology, and Biochemistry·Yoshichika KawaiJunji Terao
Feb 9, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Keiko AzumaJunji Terao
Sep 17, 2015·Journal of Food Science·Yasuaki KashinoJunji Terao
Dec 6, 2014·Clinical and Experimental Nephrology·Susumu OgawaSadayoshi Ito
Feb 15, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Esfandiar HeidarianAli Seidkhani-Nahal
Sep 10, 2014·Nutrition·Muhammad Sajid Hamid AkashShuqing Chen
Oct 11, 2016·Oxidative Medicine and Cellular Longevity·Md Asiful IslamSiew Hua Gan
Jan 31, 2017·International Journal of Molecular Sciences·Diana González-PeñaConcepción Sánchez-Moreno
Jan 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo GovernaMarco Biagi
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo
Apr 2, 2010·Journal of Agricultural and Food Chemistry·Eduvigis Roldán-MarínLars O Dragsted

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Methods Mentioned

BETA
enzymatic assay
ELISA

Software Mentioned

StatView

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