Lowering homocysteine and modifying nutritional status with folic acid and vitamin B(12) in Indian patients of vascular disease.

Journal of Clinical Biochemistry and Nutrition
Seema BhargavaLalit Mohan Srivastava

Abstract

Hyperhomocysteinemia is more commonly associated with vascular disease in Indians than in the western populations. It is caused by genetic polymorphisms or dietary deficiencies of the B vitamins. We attempted to identify the association of hyperhomocysteinemia with vitamin B(12) and folate in Indian patients of vascular disease. Homocysteine, vitamin B(12) and folate levels were estimated in 100 controls and 100 patients of vascular disease. Homocysteine estimation was repeated in 73 patients on different vitamin supplements for 6 months. Homocysteine exhibited a significant negative correlation with B(12) only in cerebrovascular disease and peripheral vascular diseasepatients, and with folate in coronary artery disease and cerebrovascular disease patients as well as controls. Single daily dose of folate was as effective as a combination of folate and cobalamin in reducing plasma homocysteine concentrations. Low levels of B(12) contribute to the higher incidence of cerebrovascular disease and peripheral vascular disease, and low folate levels account for higher prevalence of hyperhomocysteinemia in coronary artery disease and cerebrovascular disease. Moreover, irrespective of the cause of hyperhomocysteinemia, folate is known t...Continue Reading

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Citations

Mar 23, 2013·Bioinformation·Sandesh P Kamdi, Prashant Palkar
May 16, 2014·Iranian Red Crescent Medical Journal·Behrooz GhanbariHooman Bakhshandeh
Jul 18, 2015·Annals of Nuclear Medicine·Alireza Emami-ArdekaniMohamad Eftekhari
Sep 5, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Artur MierzeckiMałgorzata Kozłowska-Wojciechowska
Jan 27, 2018·Indian Journal of Clinical Biochemistry : IJCB·Seema BhargavaSangeeta Choudhury
Nov 12, 2013·Molecular and Cellular Biochemistry·Seema Bhargava, S C Tyagi
Jun 24, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Liyan LiuChanghao Sun

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