Lowering metabolic rate mitigates muscle atrophy in western fence lizards

The Journal of Experimental Biology
Jordan Balaban, Emanuel Azizi

Abstract

Extended periods of skeletal muscle disuse can cause a significant loss of contractile proteins, which compromises the ability to generate force, mechanical work or power, thus compromising locomotor performance. Several hibernating organisms can resist muscle atrophy despite months of inactivity. This resistance has been attributed to a reduction in body temperature and metabolic rate and activation of physiological pathways that counteract pathways of protein degradation. However, in these systems, such strategies are not mutually exclusive and the effects of these mechanisms can be difficult to separate. In this study, we used the western fence lizard, Sceloporus occidentalis, as an ectothermic model to determine whether a reduction in metabolic rate is sufficient to resist muscle atrophy. We induced atrophy through sciatic denervation of the gastrocnemius muscle and housed lizards at either 15 or 30°C for 6-7 weeks. Following treatment, we used muscle ergometry to measure maximum isometric force, the force-velocity relationship and contractile dynamics in the gastrocnemius. This approach allowed us to relate changes in the size and morphology to functional metrics of contractile performance. A subset of samples was used to ...Continue Reading

References

Nov 1, 1976·The American Journal of Physiology·A MaierV R Edgerton
Sep 1, 1979·Pflügers Archiv : European journal of physiology·G Boyes, I Johnston
Nov 9, 1979·Science·A F Bennett, J A Ruben
Jan 1, 1990·Journal of Applied Physiology·D B Thomason, F W Booth
Jun 1, 1987·Experimental Neurology·A M WiniarskiV R Edgerton
Jun 1, 1986·Journal of Applied Physiology·R H FittsB R Unsworth
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·R S Hikida, W J Bock
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·I Jirmanová, J Zelená
May 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F W Booth
Nov 1, 1993·International Journal of Sports Medicine·J M SoaresH J Appell
Jul 1, 1993·International Journal of Sports Medicine·J W VeldhuizenJ M Greep
Apr 1, 1993·Journal of Applied Physiology·D E BeboutP D Wagner
Nov 27, 2002·Muscle & Nerve·Vincent J Caiozzo
Jan 18, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·Y OhiraV R Edgerton
Feb 18, 2004·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·J C McDonaghD G Stuart
Feb 24, 2004·Annual Review of Physiology·Fritz Geiser
Sep 28, 2004·Physiological and Biochemical Zoology : PBZ·Bryan C RourkeVincent J Caiozzo
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas J HudsonGregory S Harper
May 13, 2006·Physiological and Biochemical Zoology : PBZ·Helen M MulemeJames F Staples
Jun 30, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Iwao OkamotoMasashi Kurimoto
Jun 30, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hitomi OhtaShigeharu Fukuda
Feb 10, 2007·Journal of Applied Physiology·Scott K PowersJoseph M McClung
Mar 29, 2007·Physiological and Biochemical Zoology : PBZ·T D LohuisP A Iaizzo
Apr 7, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Beth L MantleCraig E Franklin
Aug 13, 2010·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Megan M NowellBryan C Rourke
Apr 5, 2011·Antioxidants & Redox Signaling·Scott K PowersDavid S Criswell
May 25, 2012·The Journal of Experimental Biology·David C LinCharles T Robbins
Dec 27, 2012·Disease Models & Mechanisms·Paolo Bonaldo, Marco Sandri
Mar 23, 2013·The FEBS Journal·Stefano SchiaffinoMarco Sandri
Jun 13, 2014·The Journal of Experimental Biology·James F Staples
Jan 9, 2015·The Journal of Experimental Biology·Kenneth B Storey
Mar 17, 2016·Biomolecular Concepts·Shannon N Tessier, Kenneth B Storey
Apr 12, 2016·Comprehensive Physiology·James F Staples

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