Apr 1, 1976

LP-X in newborns: increased incidence of positive tests without cholestasis (author's transl)

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
I Witt, M Ober

Abstract

The investigation of 194 newborns has shown that during the first weeks of life the abnormal lipoprotein-X (LP-X) was present in the serum of nearly 50% of the infants, with no clinical chemical evidence of cholestasis. The percentage of LP-X positive tests was even higher in the group of immature newborns (65%). There was no correlation between the bilirubin concentration and the detection of LP-X. The activities of leucine arylamidase (EC 3.4.1.1) and gamma-glutamyltransferase (EC 2.3.2.2) as well as the concentrations of total and free cholesterol did not differ in the LP-X positive and negative infants. Except in one case, LP-X was never detectable on the first day of life. The earliest date of appearance was the second day. In the serum of some infants, who were LP-X positive shortly after birth, the lipoprotein could still be found at the age of 2--3 months. The incidence of LP-X was not higher in newborns with blood group incompatibility than in newborns with unspecific hyperbilirubinaemia. After exchange transfusions LP-X disappeared in most cases, but it could later often be detected again. In some newborns, who were LP-X negative a few days after birth LP-X was first detected at the age of 2-3 months. The LP-X test is...Continue Reading

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Mentioned in this Paper

Epicholesterol
Cholestasis in Newborn
Hyperbilirubinemia
Gamma-glutamyl transferase
Methoxyleucine Aminopeptidase
LDL-1
Non-esterified cholesterol
Bilirubin, (4E,15E)-Isomer
Gamma Glutamyl Transferase Measurement
Neonatal Prematurity

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