Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis

PLoS Neglected Tropical Diseases
Patrícia A E AbreuAntonio J B Magaldi

Abstract

Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality.

References

Jan 1, 1992·Nephron·A J MagaldiA S Rocha
Oct 1, 1989·The Journal of Hospital Infection·J M CampistolL Revert
Feb 11, 1987·Journal of Immunological Methods·M M McKinney, A Parkinson
May 1, 1985·Diagnostic Microbiology and Infectious Disease·C H Chun, M J Raff
Jun 1, 1984·Southern Medical Journal·D A Johnson, H S Etter
Mar 1, 1994·Revista Do Instituto De Medicina Tropical De São Paulo·R MartinelliH Rocha
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C MarottoA C Seguro
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Chih-Wei YangChiu-Ching Huang
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L T O NascimentoE A L Martins
Jul 27, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R R RamosP L Ho
Mar 16, 2005·FEMS Microbiology Letters·Marcia GamberiniAna L T O Nascimento
Aug 11, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexandre Braga Libório
Apr 20, 2006·Infection and Immunity·Ashutosh VermaBrian Stevenson
Sep 7, 2006·Infection and Immunity·Angela S BarbosaAna L T O Nascimento
May 1, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Regina C R M Abdulkader, Marcos Vinicius Silva
Jul 16, 2008·Seminars in Nephrology·Lúcia AndradeAntonio Carlos Seguro
Mar 31, 2009·The American Journal of Emergency Medicine·Michael D NaussArthur M Pancioli
Apr 4, 2009·Nephron. Clinical Practice·Elizabeth F DaherAlexandre B Libório
Feb 18, 2010·Infection and Immunity·Ashutosh VermaBrian Stevenson
Mar 11, 2010·Virchows Archiv : an International Journal of Pathology·Eduardo Rocha AraujoThales De Brito
Dec 5, 2012·Veterinary Microbiology·Gerald L Murray
Jul 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Nadezda Petejova, Arnost Martinek
Sep 18, 2015·PLoS Neglected Tropical Diseases·Federico CostaAlbert I Ko
Feb 20, 2016·PLoS Neglected Tropical Diseases·Derrick E FoutsJoseph M Vinetz

❮ Previous
Next ❯

Citations

Mar 24, 2018·Frontiers in Cellular and Infection Microbiology·Íris A de CastroLourdes Isaac
May 31, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Thales De BritoPatrícia Antonia Estima Abreu
Mar 16, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Voon Kin ChinZ Sekawi
Apr 26, 2019·International Journal of Molecular Sciences·Kurt T K GiulianiPedro H F Gois
Nov 12, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Silvia D'Andretta IgleziasThales De Brito

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
urine collection

Software Mentioned

GraphPad Prism
AxionVision

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Rinsho byori. The Japanese journal of clinical pathology
S Kasuga
Archivos del Instituto de Farmacología Experimental (Medicina)
F Sánchez Ramos, S León Marcano
Journal of Cardiothoracic and Vascular Anesthesia
Kyoung-Woon JoungIn-Cheol Choi
© 2022 Meta ULC. All rights reserved