LPA Promotes T Cell Recruitment through Synthesis of CXCL13

Mediators of Inflammation
Weili HuiSylvain G Bourgoin

Abstract

Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and with exacerbation of the response when LPA was administered after a pretreatment with TNF-α, a key inflammatory cytokine. LPA mediates recruitment of leukocytes, including that of CD3(+) cells into unprimed and TNF-α-primed air pouches. CXCL13 neutralization using a blocking antibody injected into air pouches prior to administration of LPA into TNF-α-primed air pouches decreased CD3(+) cell influx. Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell recruitment and participates in regulation of the inflammatory response.

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Citations

Dec 23, 2015·Bioorganic & Medicinal Chemistry Letters·Sébastien CardinalNormand Voyer
Nov 11, 2017·Frontiers in Cellular and Infection Microbiology·Hong-Li LiXiao-Jun Wu
Sep 1, 2019·Journal of Autoimmunity·Christiana MagkriotiVassilis Aidinis
Dec 19, 2017·International Immunopharmacology·Xiangwei YuanXianlong Zhang

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Methods Mentioned

BETA
ELISA
flow cytometry
FACS
Profiler
lavage
Antibody Array assay

Software Mentioned

Prism

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