LPA receptor 4 deficiency attenuates experimental atherosclerosis.

Journal of Lipid Research
Liping YangSusan S Smyth

Abstract

The widely expressed lysophosphatidic acid (LPA) selective receptor 4 (LPAR4) contributes to vascular development in mice and zebrafish. LPAR4 regulates endothelial permeability, lymphocyte migration, and hematopoiesis, which could contribute to atherosclerosis. We investigated the role of LPAR4 in experimental atherosclerosis elicited by adeno-associated virus expressing PCSK9 to lower LDL receptor levels. After 20 weeks on a Western diet, cholesterol levels and lipoprotein distribution were similar in WT male and Lpar4Y/- mice (P = 0.94). The atherosclerotic lesion area in the proximal aorta and arch was ∼25% smaller in Lpar4Y/- mice (P = 0.009), and less atherosclerosis was detected in Lpar4Y/- mice at any given plasma cholesterol. Neutral lipid accumulation in aortic root sections occupied ∼40% less area in Lpar4Y/- mice (P = 0.001), and CD68 expression was ∼25% lower (P = 0.045). No difference in α-smooth muscle actin staining was observed. Bone marrow-derived macrophages isolated from Lpar4Y/- mice displayed significantly increased upregulation of the M2 marker Arg1 in response to LPA compared with WT cells. In aortic root sections from Lpar4Y/- mice, heightened M2 "repair" macrophage marker expression was detected by CD2...Continue Reading

References

Apr 28, 2001·Prostaglandins & Other Lipid Mediators·G Tigyi
Jun 19, 2002·Biochimica Et Biophysica Acta·Wolfgang Siess
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mei-Zhen CuiXuemin Xu
Oct 14, 2003·Cardiovascular Research·James C Russell
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaime LlodráGwendalyn J Randolph
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kathleen M RuppelShaun R Coughlin
Dec 19, 2006·The Journal of Biological Chemistry·Keisuke YanagidaTakao Shimizu
Jan 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Zehra PamuklarSusan S Smyth
Jul 1, 2008·Biochimica Et Biophysica Acta·Susan S SmythAndrew J Morris
Sep 2, 2008·Biochimica Et Biophysica Acta·Gábor Tigyi
Oct 10, 2008·Molecular Biology of the Cell·Zendra LeeXianjun Fang
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·A J MorrisS S Smyth
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Ji Woong ChoiJerold Chun
May 1, 2010·The American Journal of Pathology·Martine BotErik A L Biessen
Jun 15, 2011·The Journal of Clinical Investigation·Xudong LiaoMukesh K Jain
Jul 13, 2011·Journal of Biochemistry·Keisuke Yanagida, Satoshi Ishii
Oct 6, 2011·The Journal of Biological Chemistry·Hiroshi YukiuraJunken Aoki
Jan 24, 2012·Cell·Wouter H Moolenaar, Timothy Hla
Mar 20, 2014·Journal of Lipid Research·Yun C YungJerold Chun
Jan 11, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Péter Tibor DancsZoltán Benyó
Jun 27, 2017·The Journal of Clinical Investigation·Karishma RahmanEdward A Fisher
Aug 3, 2017·Biochemical and Biophysical Research Communications·Linmu ChenChao Yu

❮ Previous
Next ❯

Citations

Nov 16, 2019·American Journal of Medical Genetics. Part a·A J AgopianUNKNOWN Pediatric Cardiac Genomics Consortium
Oct 28, 2019·Cancers·Eleanna KaffeVassilis Aidinis
Jul 22, 2020·Current Opinion in Lipidology·Jillian Davidson, Dino Rotondo

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.