LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway

Journal of Experimental & Clinical Cancer Research : CR
Chun-Hua WeiXiao-Rong Dong

Abstract

Brain metastasis (BM) is associated with poor prognosis, recurrence, and death in patients with non-small cell lung cancer (NSCLC). Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been reported to be involved in the progression, metastasis and recurrence of malignancies. However, the potential role of LPCAT1 in NSCLC remains poorly understood. This study was aimed to identify genes involved in lung adenocarcinoma (LUAD) brain metastasis, and look into the role of LPCAT1 in LUAD progression. We used integrative genomic analysis to identify genes involved in lung adenocarcinomas. LPCAT1 expression was evaluated in tumor tissues from LUAD patients and LUAD cell lines. The role of LPCAT1 was subsequently investigated both in vitro and in vivo. The mechanism underlying the involvement of LPCAT1 in LUAD progression was explored with the activator of PI3K/AKT pathway. RNA sequencing was performed to confirm the involvement of LPCAT1 and associated pathway in LUAD brain metastasis. LPCAT1 was up-regulated in LUAD tissues and cell lines. shRNA-mediated depletion of LPCAT1 not only abrogated cell proliferation, migration and invasion in vitro, but also arrested tumor growth and brain metastases in vivo. Notably, LPCAT1 at least pa...Continue Reading

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Citations

May 1, 2019·Journal of Gastroenterology and Hepatology·Yufeng ZhuFeng Ding
Feb 19, 2020·Bioscience Reports·Dan-Dan HuGuo-Liang Yang
Feb 26, 2020·International Journal of Molecular Sciences·Aaron C TanMustafa Khasraw
Jan 9, 2021·Cell Death & Disease·Hongsheng LiuYingyi Wang
Feb 5, 2021·Frontiers in Oncology·Yalin KangXianglin Yuan
Apr 23, 2021·Molecular & Cellular Proteomics : MCP·Zhiao ShiBing Zhang
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Geting WuJianhua Zhou
Aug 3, 2021·Frontiers in Oncology·Lumeng LuoXiaofei Zhang
Aug 7, 2021·The Journal of Investigative Dermatology·Yingjian HuangYan Zheng
Oct 1, 2020·ACS Applied Materials & Interfaces·Yali JunQi-Long Wang
Aug 23, 2021·Cancer Cell International·Rong-Quan HeGang Chen

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Datasets Mentioned

BETA
GSE7670
GSE126548

Methods Mentioned

BETA
PCR
electrophoresis
immunoprecipitation
xenograft
RNA-Seq
biopsies
cDNA library construction
transfection
co-IP

Software Mentioned

Oncomine
DAVID
Bowtie2
Funrich
Cufflink
Quantity One
limma
ModFit LT
GSEA
Gene Set Enrichment Analysis ( GSEA )

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