PMID: 9527358Apr 4, 1998Paper

LPS from Actinobacillus actinomycetemcomitans and production of nitric oxide in murine macrophages J774

European Journal of Oral Sciences
I J Blix, K Helgeland

Abstract

Nitric oxide (NO) plays a complex role in the modulation of the inflammatory response, having either a pro-inflammatory or a protective role. Actinobacillus actinomycetemcomitans is considered an important etiological agent in localized juvenile periodontitis. We have studied the effect of lipopolysaccharide (LPS) extracted from this periodontopathogenic bacterium on NO synthesis in an in vitro murine macrophage system. LPS from A. actinomycetemcomitans induced a significant production of NO even at concentrations as low as 1 ng/ml, whereas LPS from E. coli had to be added in concentrations of 100 ng/ml to obtain similar effects. Production of NO was blocked by NG-nitro-L-arginine methylester, and pre-treatment of LPS from A. actinomycetemcomitans with polymyxin B abolished the production of NO, while prostaglandin E2 enhanced the synthesis of NO.

Citations

Mar 4, 2006·Journal of Periodontology·David W PaquetteCsaba Szabó
Jan 16, 2008·Journal of Oral Science·Vanessa G S ReherRodrigo V Soares
May 15, 2001·Journal of Clinical Periodontology·A AurerF Culo
Oct 5, 2002·Oral Diseases·A C BatistaV S Lara
Sep 30, 2010·The Bulletin of Tokyo Dental College·Takayuki SaitoKaoru Sakurai
Aug 23, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Raquel Assed Bezerra da SilvaAlexandra Ivo de Medeiros
Sep 1, 2005·Journal of Clinical Periodontology·P N MadianosD F Kinane
Oct 15, 2009·International Endodontic Journal·R A S S RochaP Nelson-Filho
Oct 27, 2006·Oral Microbiology and Immunology·J AlayanC S Farah
Jun 1, 2004·Journal of Applied Oral Science : Revista FOB·Mario Roberto LeonardoPaulo Nelson-Filho
Sep 1, 2005·Journal of Applied Oral Science : Revista FOB·Celso Emanoel de Souza QueirozWelington Dinelli
May 3, 2001·Journal of Dental Research·Z LohinaiC Szabó

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