LPS promotes the expression of PD-L1 in gastric cancer cells through NF-κB activation

Journal of Cellular Biochemistry
Hui LiYao-Zhou Tian

Abstract

Gastric cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. Gastric infections, such as helicobacter pylori, can induce the occurrence of gastric cancers. However, the role of gastric infection in gastric cancer development is unclear. Programmed death-ligand 1 (PD-L1, B7-H1) is a member of the B7 family of cell surface ligands, which binds the PD-1 transmembrane receptor and inhibits T-cell activation within cancer tissues. It has been reported that the expression of PD-L1 is inversely related to the prognosis of patients with gastric cancers. Therefore, the regulation of PD-L1 expression in gastric cancers needs to be studied. In the current study, we explored the possible effects of lipopolysaccharide (LPS) on PD-L1 expression in gastric cancer cells. We observed that LPS stimulation could markedly increase PD-L1 expression in gastric cancer cells. Furthermore, we found that nuclear factor-κB (NF-κB) activation was involved in PD-L1 expression in gastric cancer cells exposed to LPS stimulation through p65-binding to the PD-L1 promoter. Taken together, these data indicate that gastric infection might promote the development of gastric cancers thought the LPS-NF-κB-PD-L1 axis.

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Citations

May 30, 2020·International Journal of Oncology·Xiuhua KangGuilan Wen
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu
Jun 4, 2020·International Journal of Molecular Sciences·Annika C BetzlerCornelia Brunner
Dec 31, 2020·Microbial Pathogenesis·YaLi DengRan Liu
Dec 17, 2020·Frontiers in Immunology·Fabrizio AntonangeliFrancesca Di Rosa
Jan 9, 2021·Journal of Hematology & Oncology·Ming YiKongming Wu
Mar 13, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Zhiyan RuanXinguo Su

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