LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia

Genes, Brain, and Behavior
Pratima PandeyBalraj Mittal

Abstract

Difference in genetic makeup of lipid metabolizing proteins may increase susceptibility to dementia. The aim of this study was to investigate variations in two lipid metabolizing genes, low-density lipoprotein receptor-related protein-associated protein gene (LRPAP) and apolipoprotein E (APOE), in vascular and degenerative dementias. This hospital-based association study included 147 patients with dementia and 163 age-matched controls. Genotyping for LRPAP1 intron 5 insertion/deletion and APOEHhaI polymorphism was carried out by polymerase chain reaction (PCR)/PCR-restriction fragment length polymorphism method. The frequency of DD genotype and *D allele of LRPAP gene was high in degenerative dementias compared with controls (76.6% vs. 44.8% and 86.4% vs. 69.3%, respectively) suggesting increased susceptibility [P < 0.0001, odds ratio (OR) =3.76 for DD genotype and P < 0.0001, OR = 2.80 for D allele]. Vascular dementia patients showed statistically insignificant but increasing trend for allele I (40.0% vs. 30.7%). We also observed significant association of APOEepsilon4 allele with degenerative dementias (P < 0.0001, OR =5.35). Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to deg...Continue Reading

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Citations

Oct 15, 2009·The Journal of Biological Chemistry·Takahisa Kanekiyo, Guojun Bu
Feb 8, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Neeraj Kumar SinghNeelam Chhillar
May 12, 2012·Journal of Lipids·Ellen E QuillenMichael C Mahaney
Dec 30, 2015·Experimental Cell Research·Pablo Ríos-MarcoJosé M Jiménez-López
Oct 23, 2012·Journal of Cellular Physiology·Ahmed A RehmanFahim H Khan

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