LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson's Disease.

Frontiers in Neurology
Véronique Dorval, Sébastien S Hébert

Abstract

Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of both familial and sporadic PD. One critical question is how PD-associated LRRK2 mutations cause neurodegeneration. Here, we discuss recent findings related to LRRK2-mediated regulation of gene expression and translation and provide a critical assessment of the current models that are used to address the impact of LRRK2 on the transcriptome. A better understanding of these mechanisms could provide important new clues into the function of LRRK2 during both normal and pathological conditions.

Citations

Apr 5, 2013·PloS One·Ovidiu D IancuRobert Hitzemann
Jan 16, 2014·PloS One·Véronique DorvalSébastien S Hébert
Jun 21, 2015·Trends in Molecular Medicine·Jean-Marc TaymansMarie-Christine Chartier-Harlin
Feb 2, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tina De WitEvy Lobbestael
Oct 6, 2016·Molecular Medicine·Utpal BhadraManika Pal-Bhadra
Jul 7, 2018·Frontiers in Molecular Neuroscience·Andreas AufschnaiterSabrina Büttner
Apr 29, 2016·Neurology. Genetics·Rivka InzelbergEitan Friedman
Oct 21, 2016·Annals of Neurology·Rivka InzelbergEsther Azizi

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Methods Mentioned

BETA
GTPase
transgenic
co-immunoprecipitation

Software Mentioned

GeneChip Mouse Genome 430
ingenuity pathway analysis ( IPA )

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