LruA and LruB antibodies in sera of humans with leptospiral uveitis.

Clinical and Vaccine Immunology : CVI
Ashutosh VermaJohn F Timoney

Abstract

Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that cross-reacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.

References

Jun 1, 1973·Applied Microbiology·J R ColeA R Pursell
Mar 1, 1981·Archives of Ophthalmology·W P BogerR M Robb
Jul 1, 1993·The British Journal of Ophthalmology·E La HeyA Kijlstra
Jul 1, 1997·American Journal of Ophthalmology·S R RathinamP Namperumalsamy
Aug 5, 1998·Ocular Immunology and Inflammation·M G MartinsM T de Abreu
Jun 24, 2000·Archives of Ophthalmology·I ChowersS Merin
Aug 6, 2000·American Journal of Ophthalmology·G C Brown
Sep 27, 2000·The British Journal of Ophthalmology·S R RathinamE T Cunningham
Nov 21, 2002·Current Opinion in Ophthalmology·S R Rathinam
Jul 18, 2003·Journal of Medical Microbiology·C Gowri PriyaV R Muthukkaruppan
Apr 27, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·R A HartskeerlB Wollanke
Feb 23, 2005·Journal of Dental Research·L M Al-OtaibiT W J Poate
Oct 7, 2005·Arthritis Research & Therapy·Yu LuEdward K L Chan
Nov 12, 2005·Seminars in Ophthalmology·Adriana A BonfioliFernando Orefice
Nov 16, 2006·Journal of Medical Genetics·Rosalie E FernerAmanda Kirby

❮ Previous
Next ❯

Citations

Sep 17, 2009·Nature Reviews. Microbiology·Albert I KoMathieu Picardeau
May 29, 2009·The Journal of Biological Chemistry·Yi-Pin LinYung-Fu Chang
Jan 13, 2012·Clinical and Vaccine Immunology : CVI·Ashutosh VermaJohn F Timoney
Nov 13, 2012·PLoS Neglected Tropical Diseases·Jessica N RicaldiMichael A Matthias
Oct 15, 2009·Annals of Tropical Medicine and Parasitology·S B CraigD B McKay
Dec 2, 2014·Pathogens·Jason S LehmannDerrick E Fouts
Aug 29, 2013·Current Opinion in Infectious Diseases·Jessica N RicaldiMichael A Matthias
Mar 19, 2013·Zoonoses and Public Health·A Verma, B Stevenson
Mar 11, 2015·The Journal of Small Animal Practice·S SchullerJ Sykes
Oct 14, 2010·Equine Veterinary Journal. Supplement·B C Gilger
Sep 8, 2012·Journal of Medical Microbiology·Subha SivakolunduManjula Sritharan
Jul 21, 2015·The Veterinary Journal·Fernando MalalanaCatherine McGowan
May 22, 2013·Critical Reviews in Microbiology·Veerapandian Raja, Kalimuthusamy Natarajaseenivasan
Jul 30, 2014·Frontiers in Immunology·Theodoros Kelesidis
May 20, 2015·Infection and Immunity·Azad EshghiMathieu Picardeau
Feb 24, 2018·ILAR Journal·Brian C Gilger
Apr 21, 2017·Frontiers in Immunology·Alexei ChristodoulidesTheodoros Kelesidis
Jan 27, 2019·BMC Infectious Diseases·Alejandra de-la-TorreJorge Enrique Gómez-Marín
Nov 28, 2012·Indian Journal of Medical Microbiology·A KannanS R Rathinam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Nucleic Acids Research
Neil D RawlingsAlex Bateman
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Pierre CornelisLiesbeth Van Oeffelen
© 2022 Meta ULC. All rights reserved