Dec 31, 1975

LSD as an agonist at mesolimbic dopamine receptors

Psychopharmacologia
P H Kelly, L Iversen

Abstract

The dopamine agonist apomorphine (1.0 mg/kg i.p.) produced an enhanced stimulation of locomotor activity compared to control animals in rats injected bilaterally 14 days previously with 6-hydroxydopamine (6OHDA) into the nucleus accumbens. (+)-Lysergic acid diethylamide (LSD) also produced a marked stimulation of locomotor activity in the 6OHDA treated animals at a dose (1.0 mg/kg i.p.) which was ineffective in control rats. (+)-Bromo-lysergic acid diethylamide (2.0 mg/kg i.p.) did not stimulate locomotor activity in 6OHDA treated rats. The locomotor stimulation produced by LSD was blocked by pretreatment with the dopamine antagonist pimozide (0.5 mg/kg i.p.). It is suggested that LSD acts as an agonist at mesolimbic dopamine receptors.

Mentioned in this Paper

Limbic System
Antalon
Lysergic Acid Diethylamide
Receptors, Drug
Hydroxydopamine
Oxidopamine
Pimozide
Septofimbrial Nucleus
Dopamine Receptor
Agonist

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