LSD produces conditioned place preference in male but not female fawn hooded rats

Pharmacology, Biochemistry, and Behavior
S M Meehan, M D Schechter

Abstract

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in conjunction with confinement in either the preferred or nonpreferred location. Control animals received confinement in both locations after administration of saline. Results indicated that rats administered LSD while sequestered in the nonpreferred location spent more time in that location during a nondrug test. This effect, indicative of a conditioned place preference, was exhibited only in male animals. Results are discussed in terms of potential sex differences that may mediate serotonergic sensitivity in the Fawn Hooded rat strain.

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Citations

Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Jon C Cole, Harry R Sumnall
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·K A PerkinsA R Caggiula
Mar 30, 2011·Pharmacology, Biochemistry, and Behavior·Jhodie R Duncan, Andrew J Lawrence
Feb 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomás PálenícekJirí Horácek
Dec 17, 2008·Behavioural Brain Research·Marisa J RubinowJanice M Juraska
Sep 5, 2015·Behavioural Brain Research·Evan J KyzarAllan V Kalueff
Oct 18, 2016·Journal of Pharmacological and Toxicological Methods·Amy K Goodwin
Oct 13, 2010·Journal of Psychopharmacology·H R SumnallJ C Cole
Oct 16, 2015·Behavioural Pharmacology·Filip TylšJiří Horáček
Jan 31, 2021·Pharmacology, Biochemistry, and Behavior·M L Shawn Bates, Keith A Trujillo

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