PMID: 11325543Apr 28, 2001Paper

Lsh, a SNF2 family member, is required for normal murine development

Biochimica Et Biophysica Acta
Theresa GeimanKathrin Muegge

Abstract

Lsh is a member of the SNF2 family of chromatin remodelers, that regulate diverse biological processes such as replication, repair and transcription. Although expression of Lsh is highly tissue specific in adult animals, Lsh mRNA is detectable in multiple tissues during embryogenesis. In order to determine the physiologic role of Lsh during murine development and to assess its unique function in adult mice, we performed targeted deletion of the Lsh gene using homologous recombination in murine embryonic stem cells. Lsh-/- embryos occurred with the expected Mendelian frequency after implantation and during embryogenesis. However, Lsh-/- mice died within a few hours after birth. Furthermore, newborn mice were 22% lower in weight in comparison with their littermates and showed renal lesions. Thus Lsh is a non-redundant member of the SNF2 family and is essential for normal murine development and survival.

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Citations

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Mar 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yongguang TaoKathrin Muegge
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