LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase

American Journal of Physiology. Lung Cellular and Molecular Physiology
V CarbajalL M Montaño

Abstract

Airway hyperresponsiveness is a key feature of asthma, but its mechanisms remain poorly understood. Leukotriene D(4) (LTD(4)) is one of the few molecules capable of producing airway hyperresponsiveness. In this study, LTD(4), but not leukotriene C(4) (LTC(4)), produced a leftward displacement of the concentration-response curve to histamine in bovine airway smooth muscle strips. Neither LTC(4) nor LTD(4) modified the concentration-response curve to carbachol. In simultaneous measurements of intracellular Ca(2+) ([Ca(2+)](i)) and contraction, histamine or carbachol produced a transient Ca(2+) peak followed by a plateau, along with a contraction. LTD(4) increased the histamine-induced transient Ca(2+) peak and contraction but did not modify responses to carbachol. Enhanced responses to histamine induced by LTD(4) were not modified by staurosporine or chelerythrine but were abolished by genistein. Western blot showed that carbachol, but not histamine, caused intense phosphorylation of extracellular signal-regulated kinase 1/2 and that LTD(4) significantly enhanced the phosphorylation induced by histamine, but not by carbachol. L-type Ca(2+) channel participation in the hyperresponsiveness to histamine was discarded because LTD(4) ...Continue Reading

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Citations

Feb 13, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Elizabeth Hernández-AlvídrezMario H Vargas
May 30, 2014·Pflügers Archiv : European journal of physiology·Mercedes PerusquíaLuis M Montaño
Dec 16, 2006·American Journal of Respiratory Cell and Molecular Biology·Jiazhen M DaiCheng-Han Lee
Dec 10, 2016·PloS One·Rayan Khaddaj-MallatÉric Rousseau
Jun 7, 2006·The Journal of Urology·Kirsten Bouchelouche, Pierre Bouchelouche
Mar 4, 2008·British Journal of Pharmacology·R A BrownC P Page
Dec 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jaime ChávezLuis M Montaño
Apr 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Paola Algara-SuárezRicardo Espinosa-Tanguma
Mar 12, 2013·Pflügers Archiv : European journal of physiology·Luis M MontañoCarlos Barajas-López
Oct 19, 2010·Pflügers Archiv : European journal of physiology·Edgar Flores-SotoLuis M Montaño
Sep 17, 2015·Advances in Nutrition·Melissa GabbsHarold M Aukema
May 24, 2017·International Journal of Molecular Medicine·Bettina SommerGeorgina Gonzalez-Avila
May 9, 2019·Stem Cells International·Héctor Solís-ChagoyánGloria A Benítez-King

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