Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats

European Journal of Pharmacology
D K SchellerF Tegtmeier

Abstract

A microdialysis probe was positioned inside the peri-infarct zone of a photochemically induced neocortical infarct in rats. Extracellular glutamate rose within 20 min after the start of infarct induction and continued to increase during the 5 h observation period to 5.5-fold the pre-infarct baseline value of 0.8 +/- 0.4 micromol/l. Glutamine increased only 1.4-fold. Changes in peri-infarct glutamate were preceded by steep rises in taurine (a 3.9-fold increase from the baseline value of 2.8 +/- 0.7 micromol/l), which coincided with spreading depressions during infarct induction. Post-treatment with lubeluzole ((S)-4-(2-benzothiazolylmethylamino)-alpha-[(3,4-difluoro-phenoxy) methyl]-1-piperidineethanol, 1.25 mg/kg i.v.), a new cerebroprotective drug, blocked the peri-infarct increases of glutamate and taurine, whereas the R-enantiomer was ineffective. Since lubeluzole has previously been shown to stereospecifically decrease glutamate-activated nitric oxide (NO) toxicity in vitro, the present in vivo stereospecific effect of lubeluzole may be related to modulation of the cascade of NO toxicity, thus preventing NO toxicity-mediated increases in extracellular glutamate. Blockade of the peri-infarct taurine response suggests that lu...Continue Reading

References

Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T IijimaK A Hossmann
Jan 1, 1990·Acta neurochirurgica·L HilleredU Ungerstedt
Jan 1, 1990·Progress in Neurobiology·M Erecińska, I A Silver
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Kocher
Jan 1, 1989·Glia·H Pasantes-Morales, A Schousboe
Aug 1, 1988·Journal of Neuroscience Research·H Pasantes Morales, A Schousboe
Feb 1, 1988·Acta Neurologica Scandinavica·M Nedergaard
May 1, 1985·Annals of Neurology·B D WatsonM D Ginsberg
Sep 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R Kanthan, A Shuaib
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H K KimelbergC Charniga
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackK A Hossmann
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichM Rosenthal
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Nedergaard, A J Hansen
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsumotoW D Heiss
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J TaguchiW D Heiss
Jun 1, 1996·Neuropharmacology·J AronowskiJ C Grotta
Feb 12, 1997·European Journal of Pharmacology·I Buchkremer-Ratzmann, O W Witte

❮ Previous
Next ❯

Citations

Feb 12, 1997·European Journal of Pharmacology·I Buchkremer-Ratzmann, O W Witte
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Lise A Labiche, James C Grotta
Mar 1, 2008·Neuropharmacology·Myron D Ginsberg
Oct 9, 2002·Current Medical Research and Opinion·Hans-Christoph Diener, Thomas C Wessel
Dec 17, 2014·Clinical Neurology and Neurosurgery·Stephen GrupkeJustin F Fraser
Oct 8, 1999·Vascular Medicine·M Davis, D Barer
Aug 14, 1999·Journal of Neurotrauma·S N KroppenstedtA W Unterberg
Aug 15, 2003·The Cochrane Database of Systematic Reviews·K W Muir, K R Lees
Mar 1, 2002·The Cochrane Database of Systematic Reviews·C GandolfoM Conti
May 22, 1998·Stroke; a Journal of Cerebral Circulation·J Lodder
Feb 1, 1997·Stroke; a Journal of Cerebral Circulation·M HaseldonckxM Borgers
Jan 11, 2001·Neurosurgery·C J Hodge, M Boakye

❮ Previous
Next ❯

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