Lubeluzole pretreatment does not provide neuroprotection against transient global cerebral ischemia in fetal sheep near term

Pediatric Research
Y GarnierRichard Berger

Abstract

The aim of the present study was to test the neuroprotective effect of the novel benzothiazol compound lubeluzole on neuronal cell damage in fetal sheep arising from global cerebral ischemia. Thirteen fetal sheep were prepared at a mean gestational age of 127 +/- 1 d (term is at 147 d). Six fetuses were treated with lubeluzole (0.33 mg/kg estimated body weight) before induction of global cerebral ischemia (-90, -60, and -30 min), while the remainder (n = 7) received solvent. Cerebral ischemia was induced by occluding both carotid arteries for 30 min. Cerebral blood flow was measured by injecting radio-labeled microspheres before (-90 min), during (+3 min and +27 min), and after (+40 min, +3 h, and +72 h) cerebral ischemia. Neuronal cell damage was assessed in the cerebrum and deeper brain structures by light microscopy. Values are given as means +/- SD. In control fetuses, blood flow to the cerebrum was reduced from 100 +/- 25 mL.100 g(-1) min(-1) to less than 20 mL.100 g(-1) min(-1) during ischemia. Shortly after ischemia, hyperperfusion occurred (217 +/- 66 mL.100 g(-1)min(-1)) followed by a tendency toward hypoperfusion (72 +/- 17 mL.100 g(-1) min(-1)) later on (+3 h). Significant differences in blood flow to the various bra...Continue Reading

References

Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G MiesK A Hossmann
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L HilleredU Ungerstedt
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W BodschK A Hossmann
May 1, 1972·Journal of the Neurological Sciences·A W Brown, J B Brierley
Oct 1, 1971·Journal of Applied Physiology·G D BuckbergD E Fixler
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupL Symon
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Feb 1, 1994·Current Opinion in Neurology·W D Heiss, R Graf
May 1, 1994·American Journal of Obstetrics and Gynecology·D H PenningB Richardson
Jan 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackK A Hossmann
Dec 1, 1993·American Journal of Obstetrics and Gynecology·H H de HaanT H Hasaart
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BackB D Watson
Jan 1, 1996·Reproduction, Fertility, and Development·R BergerA Jensen
Feb 1, 1997·Stroke; a Journal of Cerebral Circulation·M HaseldonckxM Borgers
Feb 12, 1997·European Journal of Pharmacology·I Buchkremer-Ratzmann, O W Witte
Mar 17, 1997·Brain Research. Developmental Brain Research·K WangenF Fonnum
Jan 10, 1998·European Journal of Pharmacology·D K SchellerF Tegtmeier
May 22, 1998·Stroke; a Journal of Cerebral Circulation·J Lodder
Aug 14, 1999·Journal of Neurotrauma·S N KroppenstedtA W Unterberg
May 2, 2000·Cellular and Molecular Neurobiology·K Maiese, A M Vincent
Jun 8, 2001·Journal of the Society for Gynecologic Investigation·R BergerA Jensen

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