PMID: 6310075Jan 1, 1982Paper

Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study

Journal of Pediatric Gastroenterology and Nutrition
J M Sondheimer, E P Gervaise


The efficacy of two medications commonly used in treatment of chronic functional constipation of children (CFC) was compared. Thirty-seven children (aged 3-12 years) with typical CFC were assigned at random to treatment with mineral oil or standardized senna concentrate (Senokot). The results of follow-up evaluations at 1, 3, and greater than 6 months indicate that symptom control (fecal soiling and decreased stool frequency) was significantly better in mineral-oil-treated patients. At least one recurrence of symptoms occurred in 66% of mineral-oil-treated and 89% of Senokot-treated patients. However, recurrences appeared later and less frequently in mineral-oil-treated patients. After 6 months, 55% of those treated with mineral oil had successfully discontinued regular medication. After 6 months, only 22% of Senokot-treated patients had successfully discontinued medication, while an additional 33% had stopped taking medication because of poor symptom control.


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Jul 24, 2001·Archives of Disease in Childhood·F SharifB Bourke
Nov 18, 2006·BMJ : British Medical Journal·Greg Rubin, Anne Dale
Jun 15, 2011·Italian Journal of Pediatrics·Nadeem A AfzalMike A Thomson
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Aug 18, 2016·The Cochrane Database of Systematic Reviews·Morris GordonAdrian G Thomas
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