Lubrication potential of magnesium stearate studied on instrumented rotary tablet press

AAPS PharmSciTech
Sarsvatkumar PatelArvind Kumar Bansal

Abstract

The aim of this study was to investigate the lubrication potential of 2 grades of magnesium stearate (MS) blended with a mix of dicalcium phosphate dihydrate and microcrystalline cellulose. Force-displacement, force-time, and ejection profiles were generated using an instrumented rotary tablet press, and the effect of MS mixing time (10, 20, and 30 minutes) and tableting speed (10.7, 13.8, and 17.5 rpm) was investigated. The packing index (PI), frictional index (FI), and packing energy (PE) derived from the force-displacement profiles showed that MS sample I performed better than sample II. At higher lubricant mixing times, the values of PI were observed to increase, and values of FI and PE were observed to decrease for both MS samples. Lower values of area under the curve (AUC) calculated from force-time compression profiles also showed sample I to be superior to sample II in lubrication potential. For both the samples, the values of AUC were observed to decrease with higher lubricant mixing times. Tapping volumetry that simulates the initial particle rearrangement gave values of parameter a and C(max) that were higher for sample I than sample II and also increased with lubricant mixing time. The superior lubrication potential...Continue Reading

References

Jan 1, 1978·The Journal of Pharmacy and Pharmacology·P York
Oct 1, 1978·The Journal of Pharmacy and Pharmacology·J E Rees, P J Rue
Apr 1, 1978·Journal of Pharmaceutical Sciences·T A Iranloye, E L Parrott
Aug 1, 1989·The Journal of Pharmacy and Pharmacology·R J Oates, A G Mitchell
Aug 1, 1981·The Journal of Pharmacy and Pharmacology·M Sheikh-Salem, J T Fell
Apr 1, 1997·Journal of Pharmaceutical Sciences·A Muñoz-RuizP Paronen
Mar 5, 1999·Drug Development and Industrial Pharmacy·C MatzD Becker
Jan 29, 2003·International Journal of Pharmaceutics·Osmo Antikainen, Jouko Yliruusi
Apr 10, 2004·International Journal of Pharmaceutics·Hirofumi TakeuchiYoshiaki Kawashima
Jun 2, 2005·Pharmaceutical Development and Technology·Marylène VianaDominique Chulia
Sep 24, 2005·Pharmaceutical Development and Technology·K Phanidhara RaoArvind K Bansal

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Citations

Jul 2, 2009·Drug Development and Industrial Pharmacy·Rishi KapilSanju Dhawan
Jan 15, 2014·Drug Delivery·Sruti JammulaMuddana Eswara Bhanoji Rao
Feb 7, 2012·Drug Development and Industrial Pharmacy·Patrick OkoyeRutesh H Dave
Jul 12, 2012·Drug Development and Industrial Pharmacy·Takehiko HorioShuji Matsusaka
Apr 20, 2012·Expert Opinion on Drug Delivery·Nookala Venkala Satheesh MadhavRuchi B Semwal
Sep 17, 2014·Journal of Pharmaceutical Sciences·Preetanshu PandeySherif Badawy
Sep 8, 2010·International Journal of Pharmaceutics·Ajit S NarangDivyakant S Desai
Feb 27, 2015·Pharmaceutical Development and Technology·Timuçin Uğurlu, Mekin Doğa Halaçoğlu
Jun 26, 2014·Journal of Microencapsulation·Amit Kumar DeArup Mukherjee
Sep 2, 2016·Drug Development and Industrial Pharmacy·Julia Anita GrießingerAndreas Bernkop-Schnürch
Jun 10, 2016·Drug Development and Industrial Pharmacy·Elisabeth PeetersJean-Paul Remon
May 26, 2009·AAPS PharmSciTech·Soma GhoshBiswajit Mukherjee
Nov 17, 2009·Pharmaceutical Development and Technology·Nisreen HassanJaved Ali
Jan 19, 2010·Journal of Microencapsulation·Bashar Al-TaaniAlsayed Sallam

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