Lucio's phenomenon: another case reported in Brazil

Anais Brasileiros De Dermatologia
Rodrigo MonteiroLuciena Cegatto Martins Ortigosa

Abstract

Lucio's phenomenon is defined as a variant of type 2 leprosy reaction. It is a rare event, occurring in the evolution of leprosy of Lucio and other forms of lepromatous leprosy. It has an exacerbated proliferation of Hansen bacilli in its pathophysiology, which invade blood vessel walls and injure endothelial cells, causing endothelial proliferation and decreasing the vascular lumen. This fact, associated with inflammatory reactions and changes in the coagulation system causes vascular thrombosis, ischemia, infarction and tissue necrosis, leading to the histopathological characteristic of the phenomenon. We report a case of lepromatous leprosy with irregular treatment that developed Lucio's phenomenon. Treatment with multidrug therapy, antibiotics, steroids and thalidomide achieved a favorable outcome.

References

Feb 1, 1978·Clinical Immunology and Immunopathology·F P QuismorioG J Friou
Jun 30, 2005·International Journal of Dermatology·Izelda Maria Carvalho CostaLucas Souza Carmo Nogueira
Nov 27, 2008·The American Journal of Dermatopathology·Mario MagañaMario L Magaña
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Aug 26, 2009·International Journal of Dermatology·Siew Eng Choon, Kwee Eng Tey

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Citations

Apr 29, 2014·Anais Brasileiros De Dermatologia·Joel Carlos Lastória, Marilda Aparecida Milanez Morgado de Abreu
Oct 20, 2017·Emerging Infectious Diseases·Cesar RamalPedro Legua
Jan 11, 2013·Memórias do Instituto Oswaldo Cruz·Isabel BaezaIris Estrada-Garcia
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Pushpendra SinghStewart T Cole
Jan 24, 2020·Korean journal of family medicine·Siti Nuryati Che YaWan Noor Hasbee Wan Abdullah
Mar 25, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Eduardo Vinicius Mendes RoncadaMarilda Aparecida Milanez Morgado de Abreu

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