PMID: 9443684Jan 27, 1998Paper

Ludwig symposium on biliary disorders--part I. Pathogenesis of ductal plate abnormalities

Mayo Clinic Proceedings
V J Desmet

Abstract

Intrahepatic bile ducts (IHBDs) develop from bipotential liver progenitor cells in contact with the mesenchyme of the portal vein and thus form the "ductal plates." The ductal plates are remodeled into mature tubular ducts. Lack of remodeling results in the persistence of periportal epithelial sleeves or "ductal plate malformation" (DPM). A proposal is that virtually all congenital diseases of IHBDs represent examples of DPM. Some early, severe types of extrahepatic bile duct atresia are characterized by DPM, a suggestion of a prenatal beginning of the disease. Several congenital diseases are characterized by dilatation of segments of IHBDs and variable degrees of fibrosis. Such "fibrocystic diseases" represent DPM at different levels of the biliary tree. Autosomal recessive polycystic kidney disease represents DPM of interlobular bile ducts, associated with tubular dilatation of collecting renal tubules. Congenital hepatic fibrosis may derive from the same type of liver lesion, through a superimposed destructive type of cholangiopathy associated with scarring fibrosis. Caroli's disease represents DPM of the larger IHBDs, whereas Caroli's syndrome combines the lesions of Caroli's disease and congenital hepatic fibrosis. von Mey...Continue Reading

References

Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J Desmet
Aug 1, 1992·Journal of Clinical Pathology·J MathewA D Burt
Feb 1, 1992·Cancer Genetics and Cytogenetics·J T Mascarello, H F Krous
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KidaT Terada
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetR Sciot
Dec 1, 1990·Histopathology·E A RaweilyA D Burt
Feb 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J T HjelleR B Prior
Nov 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P A Gabow
Nov 1, 1990·Kidney International·J M CobbenK Zerres
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A GabowG T Everson
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Van EykenV J Desmet
Apr 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J MilutinovicS K Ainsworth
Jul 1, 1989·Cancer Genetics and Cytogenetics·F SpelemanH Van den Berghe
Jan 1, 1987·American Journal of Medical Genetics. Supplement·T A BlankenbergJ E Dimmick
Apr 1, 1988·The American Journal of Surgical Pathology·M K Kwok, K J Lewin
May 1, 1987·Seminars in Liver Disease·C A Riely
May 1, 1987·Seminars in Liver Disease·V J Desmet
Feb 1, 1986·Radiology·G J MarchalA L Baert
Aug 1, 1970·Cancer·E B Chung
Sep 1, 1971·Journal of Medical Genetics·H Blyth, B G Ockenden
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y NakanumaG Ohta
Nov 1, 1984·Archives of Internal Medicine·P LandaisA Moynot
Jul 1, 1983·Pediatric Pathology·J T Stocker, K G Ishak
Sep 1, 1981·The Journal of Pediatrics·F AlvarezD Alagille
Jan 1, 1980·Digestive Diseases and Sciences·S A KocoshisJ D Gryboski
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K BlakolmerS C Robson
Aug 1, 1994·Seminars in Liver Disease·I D D'AgataL M Guay-Woodford
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Terada, Y Nakanuma
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Bianchi, J Reichen
Dec 1, 1993·Nature Genetics·D J PetersC D Constantinou-Deltas

❮ Previous
Next ❯

Citations

May 19, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ashish SinghalVivek Kohli
Dec 4, 2003·Current Problems in Diagnostic Radiology·Angela D Levy, Charles A Rohrmann
Sep 17, 1999·Journal of Hepatology·T J de KoningG P van Berge Henegouwen
Jan 14, 2000·Journal of Gastroenterology and Hepatology·U PoddarK Singh
Apr 30, 2005·Acta Paediatrica·O F SenyüzH Emir
Sep 10, 2002·Journal of Computer Assisted Tomography·Denis KrauséPatrick Hillon
Aug 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·P BrownS Royal
Mar 11, 2005·Journal of Clinical Gastroenterology·Mario StrazzaboscoCarlo Spirli
Jul 30, 2009·Journal of Gastroenterology and Hepatology·Matthew M Yeh
Aug 30, 2001·Radiology·A S FulcherA J Sanyal
Aug 3, 2004·BMC Gastroenterology·David L SuskindMarcus O Muench
Jul 29, 2006·Orphanet Journal of Rare Diseases·Christophe Chardot
Nov 17, 2001·American Journal of Clinical Pathology·M MorcosB Terris
Mar 28, 2012·AJR. American Journal of Roentgenology·Inês SantiagoFilipe Caseiro-Alves
Nov 4, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·M Cristina PachecoKevin E Bove
Jul 31, 2012·Gut and Liver·Seon Mee Park
Jun 3, 2014·Orphanet Journal of Rare Diseases·Wybrich R Cnossen, Joost P H Drenth
Apr 10, 2007·Current Gastroenterology Reports·Ashwin N Ananthakrishnan, Kia Saeian
Feb 27, 2008·Digestive Diseases and Sciences·Loes van KeimpemaJoost P H Drenth
Jul 29, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Javier C LendoireOscar Imventarza
Aug 7, 2014·Current Pathobiology Reports·Steven P O'HaraNicholas F LaRusso
Oct 26, 2012·International Journal of Hepatology·Alejandro Costaguta, Fernando Alvarez
Mar 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carsten Bergmann
Oct 1, 2014·Nature Reviews. Gastroenterology & Hepatology·Maria J PerugorriaJesus M Banales
Jun 18, 2009·Seminars in Immunopathology·Ya-Hui ChuangM Eric Gershwin
Apr 29, 2006·Journal of Clinical Pathology·J C HernándezJ Jordán
Feb 24, 2011·Seminars in Liver Disease·Luca Fabris, Mario Strazzabosco
Sep 8, 2011·European Journal of Pediatrics·Carsten Bergmann
Jun 27, 2013·World Journal of Gastroenterology : WJG·Marten A LantingaJoost P H Drenth
Oct 15, 2013·World Journal of Gastroenterology : WJG·Bassam Abu-WaselMichele Molinari
Feb 5, 2003·Journal of Veterinary Internal Medicine·S GörlingerT S G A M van den Ingh
Sep 18, 2012·European Journal of Pediatrics·Jurica VukovićJuraj Sprung
Oct 21, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Zhong-Xia WangXiao-He Xiao
Jan 16, 1999·Baillière's Clinical Gastroenterology·J R Poley, M J Nowicki
Nov 3, 2015·Diagnostic and Interventional Imaging·L PechJ P Cercueil
Jul 19, 2002·Clinics in Liver Disease·Milton J Finegold
Apr 8, 2016·Fetal and Pediatric Pathology·Suvradeep MitraAshim Das
Sep 22, 2001·Clinics in Liver Disease·E Molina, K R Reddy
Jun 30, 2007·The American Journal of Pathology·Luca FabrisMario Strazzabosco
Mar 25, 2014·Annals of Saudi Medicine·Ahmed Al SarkhyFowzan S Alkuraya
Jul 10, 2002·Veterinary Pathology·H YoshikawaT Yoshikawa
Jan 19, 2010·Veterinary Pathology·D L BrownJ M Cullen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

Archives of Disease in Childhood. Fetal and Neonatal Edition
F KeaneG Mieli-Vergani
Postgraduate Medical Journal
M Akoglu, B R Davidson
Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Justin CheungEric M Yoshida
© 2021 Meta ULC. All rights reserved