Lugaro's forgotten legacy: the hypothesis of negative neurotropism

Journal of the History of the Neurosciences
Matthew J Fraidakis

Abstract

Among the most fascinating riddles in neuroscience is the one concerning the poor regeneration capacity of the adult mammalian CNS. A central aetiological hypothesis for the lack of axonal regeneration in the CNS concerns the inhibitory role of myelin components of the white matter. The main exponent of this hypothesis in the 1980s and 1990s has been Martin Schwab, although before him Martin Berry and others had suggested an inhibitory role for CNS myelin. However, a hypothesis for a negative neurotropic action exerted by CNS white matter was formulated by Lugaro already in 1906. This article is a belated tribute to Lugaro's original contribution in the field of neuroregeneration.

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Citations

Jul 9, 2013·Experimental Neurology·Lars Olson
Feb 4, 2014·Journal of Neuroscience Methods·Luis E SavastanoSean I Patterson
Mar 16, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Natalia Perussi BiscolaAlexandre Leite Rodrigues Oliveira

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