LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells.

Journal of Virology
Justin C PaglinoAnthony N van den Pol

Abstract

Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect against human glioblastomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI). MVMi, MVMc, MVM-G17, tumor virus X (TVX), canine parvovirus (CPV), porcine parvovirus (PPV), rat parvovirus 1A (RPV1A), and H-3 were relatively ineffective. The four viruses with the greatest oncolytic activity, LuIII, H-1, MVMp, and MVM-G52, were tested for the ability, at a low MOI, to progressively infect the culture over time, causing cell death at a rate higher than that of cell proliferation. LuIII alone was effective in all five human glioblastomas tested. H-1 progressively infected only two of five; MVMp and MVM-G52 were ineffective in all five. To investigate the underlying mechanism of LuIII's phenotype, we used recombinant parvoviruses with the LuIII capsid replacing the MVMp capsid or with molecular alteration of the P4 promoter. The LuIII capsid enhanced efficient replication and oncolysis in MO59J gliomas cells; other gliomas tested required the entire LuIII genome to exhi...Continue Reading

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Citations

Mar 2, 2013·Journal of Virology·Sujata HalderMavis Agbandje-McKenna
Jan 30, 2015·Virology Journal·Antonio MarchiniJean Rommelaere
Apr 10, 2017·Virology·Chen MeirClaytus Davis
Apr 22, 2020·Viral Immunology·Shanan N EmmanuelMavis Agbandje-McKenna
Jul 1, 2020·Annual Review of Virology·Anna HartleyAntonio Marchini
Oct 31, 2018·Cancers·Diana SánchezMarcela Lizano
Oct 18, 2020·International Journal of Molecular Sciences·Sergio Rius-RocabertEstanislao Nistal-Villan
Mar 31, 2021·Neurosurgery Clinics of North America·Dagoberto Estevez-OrdonezJames M Markert

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