PMID: 8600878Mar 1, 1996Paper

Lumbosacral radiculopathy secondary to L5 metastatic melanoma of unknown primary

Archives of Physical Medicine and Rehabilitation
A KuW Nagler

Abstract

Lumbosacral radiculopathy secondary to spinal malignancy is rare. Spinal melanoma without cutaneous manifestations is even more unusual. We present the case of a 45-year-old physician with a history of degenerative disease of lumbar spine and chronic back pain who presented with increasing back pain with right radiculopathy despite conservative management for 6 months. Computed tomography showed a destructive lesion of the L5 vertebral body. Results from a biopsy guided by computed tomography suggested neoplasm of unknown origin. The patient underwent anterior vertebrectomy with instrumentation and fusion. Surgical pathology study results showed metastatic melanoma of unknown primary. The patient had no cutaneous manifestation of the disease. This is the first reported case of radiculopathy due to melanoma metastatic to the lumbar spine. In view of the atypical presentation of our patient's malignancy, we emphasize the importance of including malignancy of lumbar spine in the differential diagnosis of progressive lower back pain with radiculopathy.

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Citations

Dec 14, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kenichiro KakutaniMasahiro Kurosaka
Mar 15, 2006·Stereotactic and Functional Neurosurgery·Peter C GersztenJohn M Kirkwood
Oct 25, 2011·Clinical Neurology and Neurosurgery·Ozan GaniüsmenÜmit Bayol
Mar 3, 2015·Neurosurgical Focus·James P CarusoJason P Sheehan
Oct 5, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Michael A FinnMeic H Schmidt
Oct 27, 2020·The Journal of International Medical Research·Diogo Goulart CorrêaLuiz Celso Hygino da Cruz

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