PMID: 2109637Apr 23, 1990Paper

Luminal and basolateral polyamine uptake by rat small intestine stimulated to grow by Phaseolus vulgaris lectin phytohaemagglutinin in vivo

Biochimica Et Biophysica Acta
S BardoczA Pusztai

Abstract

Luminal and basolateral uptake of polyamines by the rat small intestine was studied in vivo. In the concentration range studied (0.1-5 mg per rat) 23-47% of the individual polyamines given intragastrically were found in the body after 1 h, with the small intestine retaining 4-12% of the dose. With spermidine or spermine, labelled polyamines accounted for 85-96% of the counts in the small intestine and between 72-82% were in the form given. However, with putrescine only 29-39% of the label found in the tissue remained in polyamine form and even less, 11-15%, as putrescine. Luminal uptake of polyamines was linear, non-saturable and was not stimulated when small intestinal growth was stimulated by phytohaemagglutinin (PHA). On the basolateral side of the gut, polyamine uptake was stimulated by PHA in a time-dependent way in advance of detectable growth. Overall polyamine recoveries were high (89-99%) with intraperitoneally administered spermidine and spermine. Moreover, a large proportion of the counts in the tissue (63-89%) were still in the original form. Even with putrescine, total recoveries of polyamines (72-88%) and putrescine (24-33%) were elevated in comparison with those from the lumen. Treatment of rats with alpha-difluo...Continue Reading

References

Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C E BrownJ J Katz

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Citations

Mar 1, 1992·Pflügers Archiv : European journal of physiology·A M DumontierD Tome
May 10, 1995·Molecular and Cellular Biochemistry·H M'Rabet-TouilP H Duée
Dec 1, 1990·Digestive Diseases and Sciences·P GeorgesN Romain
Oct 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·B O NilssonE Rosengren
Jun 1, 1995·FEMS Immunology and Medical Microbiology·G GrantN C Garber
Aug 1, 1996·The International Journal of Biochemistry & Cell Biology·N SeilerJ P Moulinoux
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·N E OsmanB Karlsson
Nov 13, 2004·The Journal of Nutritional Biochemistry·K MezianiD Tomé
Aug 10, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·K A Eliassen, O V Sjaastad
Apr 29, 1998·Annual Review of Physiology·H Koepsell
Jun 1, 1993·Digestive Diseases and Sciences·J P ButsF Van Hoof
Jul 14, 2006·Digestive Diseases and Sciences·Jean-Paul Buts, Nadine De Keyser
Jul 1, 1993·The British Journal of Nutrition·Y C Ge, R G Morgan
Sep 9, 2009·Experimental Gerontology·Kuniyasu SodaFumio Konishi
Oct 13, 2011·Journal of Experimental & Clinical Cancer Research : CR·Kuniyasu Soda
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·G M Murphy
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·V Milovic
Jun 1, 1995·The British Journal of Nutrition·S BardóczA Ralph
Oct 1, 1996·The British Journal of Nutrition·P DeloyerG Goessens
Apr 1, 1991·Experimental Cell Research·S A McCormack, L R Johnson
Jan 31, 2002·World Journal of Gastroenterology : WJG·V MilovicW F Caspary
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kuniyasu SodaFumio Konishi
Mar 16, 2019·International Journal of Molecular Sciences·Taro FukuiToshiki Rikiyama
Mar 21, 2007·Biochemical Society Transactions·I F Pryme
Oct 13, 2018·International Journal of Molecular Sciences·Kuniyasu Soda
Apr 4, 2021·Medical Sciences : Open Access Journal·Kuniyasu SodaTaro Fukui

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