Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage.

Brain Research
Victor FriedrichFatima A Sehba

Abstract

The pathophysiology of early ischemic injury after aneurysmal subarachnoid hemorrhage (SAH) is not understood. This study examined the acute effect of endovascular puncture-induced SAH on parenchymal vessel function in rat, using intravascular fluorescent tracers to assess flow and vascular permeability and immunostaining to assess structural integrity and to visualize platelet aggregates. In sham-operated animals, vessels were well filled with tracer administered 10s before sacrifice, and parenchymal escape of tracer was rare. At ten minutes and three hours after hemorrhage, patches of poor vascular filling were distributed throughout the forebrain. Close examination of these regions revealed short segments of narrowed diameter along many profiles. Most vascular profiles with reduced perfusion contained platelet aggregates and in addition showed focal loss of collagen IV, a principal component of basal lamina. In contrast, vessels were well filled at 24h post-hemorrhage, indicating that vascular perfusion had recovered. Parenchymal escape of intravascular tracer was detected at 10 min post-hemorrhage and later as plumes of fluorescence emanating into parenchyma from restricted microvascular foci. These data demonstrate that pa...Continue Reading

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Citations

Dec 17, 2010·Molecular Neurobiology·Fatima A SehbaJohn H Zhang
Aug 23, 2011·Journal of Neuroinflammation·Victor FriedrichFatima A Sehba
Feb 11, 2014·Translational Stroke Research·Michael K Tso, R Loch Macdonald
Dec 11, 2013·Nature Reviews. Neurology·R Loch Macdonald
Jun 27, 2014·BioMed Research International·Giulia CossuRoy Thomas Daniel
Sep 13, 2014·Translational Stroke Research·Fatima A Sehba
Apr 17, 2013·Stroke Research and Treatment·Michael K Tso, R Loch Macdonald
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
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Apr 10, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Jennifer A FronteraErrol Gordon
Mar 1, 2016·Neurological Research·Victor FriedrichFatima A Sehba
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Jan 24, 2020·Chinese Journal of Integrative Medicine·Hua-Bin ZhangSong-Sheng Shi
Jun 12, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ari DienelDevin W McBride
Jul 3, 2021·Journal of Clinical Medicine·Pervinder BhogalHans Henkes
Jun 24, 2021·Journal of Neurochemistry·Jiru ZhouHua Feng
Sep 3, 2021·Stroke; a Journal of Cerebral Circulation·Mario ZanatyDavid Hasan
Sep 10, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masato NaraokaHiroki Ohkuma

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