PMID: 95Jul 1, 1975

Luminescence study of the effect of temperature on the conformational state of fibrinogen

Biofizika
S V KonevE V Barkovskiĭ

Abstract

Results are presented of measuring fibrinogen fluorescence parameters in temperature range of 20-80 degrees C at different pH of the solution. It was found that the temperature increase from 20 to 40 degrees C for solutions with pH of 4,5-9,3 were not accompanied by the conformational changes of fibrinogen macromolecules. In the temperature range of 40-50 degrees C for neutral solutions conformational reconstruction of fibrinogen of undenatured character took place. Temperature increase above 50-55 degrees C brings about significant structural changes of fibrinogen molecule which are of denaturation nature.

Related Concepts

Gamma-Fibrinogen
Hydrogen-Ion Concentration
Fluorescence Spectroscopy

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