Luminescence thermometry for in situ temperature measurements in microfluidic devices

Lab on a Chip
Robin G GeitenbeekAndries Meijerink

Abstract

Temperature control for lab-on-a-chip devices has resulted in the broad applicability of microfluidics to, e.g., polymerase chain reaction (PCR), temperature gradient focusing for electrophoresis, and colloidal particle synthesis. However, currently temperature sensors on microfluidic chips either probe temperatures outside the channel (resistance temperature detector, RTD) or are limited in both the temperature range and sensitivity in the case of organic dyes. In this work, we introduce ratiometric bandshape luminescence thermometry in which thermally coupled levels of Er3+ in NaYF4 nanoparticles are used as a promising method for in situ temperature mapping in microfluidic systems. The results, obtained with three types of microfluidic devices, demonstrate that temperature can be monitored inside a microfluidic channel accurately (0.34 °C) up to at least 120 °C with a spot size of ca. 1 mm using simple fiber optics. Higher spatial resolution can be realized by combining luminescence thermometry with confocal microscopy, resulting in a spot size of ca. 9 μm. Further improvement is anticipated to enhance the spatial resolution and allow for 3D temperature profiling.

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Citations

Aug 5, 2020·Chemistry : a European Journal·Carolien M VisPieter Bruijnincx
Nov 11, 2020·Physical Chemistry Chemical Physics : PCCP·Mikhail B VialtsevValentina V Utochnikova
Nov 12, 2020·Foods·Emanuela DragoPatrizia Perego
Sep 10, 2020·ACS Applied Materials & Interfaces·Wojciech PiotrowskiLukasz Marciniak
Apr 21, 2020·ACS Nano·Thomas HartmanBert M Weckhuysen
Aug 28, 2020·ACS Applied Materials & Interfaces·Michele BackSetsuhisa Tanabe

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Methods Mentioned

BETA
confocal microscopy
chip
chips
confocal reflection microscopy

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