Luminescent gold nanocluster-based sensing platform for accurate H2 S detection in vitro and in vivo with improved anti-interference

Light, Science & Applications
Qi YuWei Huang

Abstract

Gold nanoclusters (Au NCs) are promising luminescent nanomaterials due to their outstanding optical properties. However, their relatively low quantum yields and environment-dependent photoluminescence properties have limited their biological applications. To address these problems, we developed a novel strategy to prepare chitosan oligosaccharide lactate (Chi)-functionalized Au NCs (Au NCs@Chi), which exhibited emission with enhanced quantum yield and elongated emission lifetime as compared to the Au NCs, as well as exhibited environment-independent photoluminescence properties. In addition, utilizing the free amino groups of Chi onto Au NCs@Chi, we designed a FRET-based sensing platform for the detection of hydrogen sulfide (H2S). The Au NCs and the specific H2S-sensitive merocyanine compound were respectively employed as an energy donor and acceptor in the platform. The addition of H2S induced changes in the emission profile and luminescence lifetime of the platform with high sensitivity and selectivity. Utilization of the platform was demonstrated to detect exogenous and endogenous H2S in vitro and in vivo through wavelength-ratiometric and time-resolved luminescence imaging (TLI). Compared to previously reported luminescent...Continue Reading

References

Apr 1, 1995·Biophysical Journal·C L HutchinsonE M Sevick-Muraca
May 14, 2005·Nature Reviews. Neuroscience·Christopher J FredericksonAshley I Bush
Aug 4, 2007·Angewandte Chemie·Chih-Ching HuangHuan-Tsung Chang
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stanley W BotchwayJ A Gareth Williams
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andreas PapapetropoulosCsaba Szabó
Apr 2, 2010·Chemical Reviews·Mikhail Y Berezin, Samuel Achilefu
Apr 20, 2010·Angewandte Chemie·David A GiljohannChad A Mirkin
May 5, 2010·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Chen ZhouJie Zheng
Jan 8, 2011·Annual Review of Pharmacology and Toxicology·Ling LiPhilip K Moore
Dec 2, 2011·Chemical Society Reviews·Lev Dykman, Nikolai Khlebtsov
Feb 3, 2012·Chemical Reviews·Krishnendu SahaVincent M Rotello
Jan 31, 2013·Journal of the American Chemical Society·Jun LiuChuan He
Mar 9, 2013·Nature Photonics·Scott S HowardChris Xu
Mar 26, 2013·Chemical Society Reviews·Peng Wu, Xiu-Ping Yan
May 9, 2013·Accounts of Chemical Research·Sung Hei YauTheodore Goodson
Aug 10, 2013·Accounts of Chemical Research·Gady Konvalina, Hossam Haick
Sep 13, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Sharbari Palmal, Nikhil R Jana
Mar 13, 2014·Chemical Reviews·Guanying ChenXiaoyuan Chen
Jun 19, 2014·Pflügers Archiv : European journal of physiology·Yusuke KumaiSteve F Perry
Sep 11, 2014·Angewandte Chemie·Sanyang HanXiaogang Liu
Oct 3, 2014·Analytical Chemistry·Li-Yi ChenHuan-Tsung Chang
Nov 26, 2014·Chemical Reviews·Eun-Kyung LimKwangyeol Lee
Jan 15, 2015·Current Opinion in Nephrology and Hypertension·Kim M HolwerdaA Titia Lely
Jan 27, 2015·Chemical Society Reviews·Otto S Wolfbeis
Mar 18, 2015·Chemical Society Reviews·K David Wegner, Niko Hildebrandt
Apr 29, 2015·Chemical Society Reviews·Serena Silvi, Alberto Credi
May 20, 2015·Chemical Society Reviews·Frederico R BaptistaS J Quinn
Jun 27, 2015·Chemical Reviews·Wen ZhouXiaoyuan Chen
Jul 28, 2015·Chemical Society Reviews·Jingjing LiJun-Jie Zhu
Sep 22, 2015·Advanced Materials·Si Wu, Hans-Jürgen Butt
Sep 25, 2015·Chemical Society Reviews·Yu TaoXiaogang Qu

❮ Previous
Next ❯

Citations

Mar 13, 2019·Annual Review of Analytical Chemistry·Guoxin RongHeather A Clark
Apr 9, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Chak-Shing KwanKen Cham-Fai Leung
Mar 31, 2018·IUBMB Life·Virender Kumar PalAmit Singh
Sep 28, 2018·Nanoscale Research Letters·Navdeep KaurTsung-Rong Kuo
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi HeXueji Zhang
May 2, 2020·Analytical and Bioanalytical Chemistry·S Madanan AnjuSony George
Sep 2, 2020·Saudi Journal of Biological Sciences·Sello Lebohang ManotoPatience Mthunzi-Kufa
Apr 23, 2021·The Journal of Physical Chemistry Letters·Pankaj GhildiyalMichael R Zachariah
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim
Jul 11, 2018·ACS Applied Materials & Interfaces·Pietro DelcanaleCristian A Strassert
Sep 14, 2021·The Journal of Physical Chemistry Letters·Debkumar Bera, Nirmal Goswami

❮ Previous
Next ❯

Methods Mentioned

BETA
FRET
transmission electron microscopy
X-ray
dynamic light scattering
surface plasmon resonance
amidation
flow cytometry
confocal microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.