Luminex and antibody detection in kidney transplantation.

Clinical and Experimental Nephrology
Antonietta PicasciaClaudio Napoli

Abstract

Preformed anti-human leukocyte antigen (HLA) antibodies have a negative effect on kidney transplantation outcome with an increased rejection rate and reduction in survival. Posttransplantation production of donor-specific anti-HLA antibodies is indicative of an active immune response and risk of transplantation rejection. For many years the primary technique for anti-HLA antibody detection was complement-dependent cytotoxicity (CDC), which has been integrated by solid-phase assays as HLA antigen-coated bead methods (Luminex). This new technological approach has allowed identification of anti-HLA antibodies, not detectable using conventional CDC method, in patients awaiting kidney transplantation. Moreover, use of Luminex technology has enabled better definition of acceptable or unacceptable antigens favoring transplantation in highly immunized patients. However, there are still many unresolved issues, including the clinical relevance of antibodies detected with this system.

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Citations

Jan 30, 2014·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Claudio NapoliStefano Federico
Jun 4, 2014·The Journal of Clinical Investigation·Paolo Cravedi, Peter S Heeger
Apr 15, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·David AnsariJohan Nilsson
Oct 26, 2013·Transplantation Proceedings·K KuriharaM Tanaka
Aug 31, 2014·Immunology Letters·Antonietta PicasciaClaudio Napoli
Aug 18, 2016·Transplantation Reviews·Antonietta PicasciaClaudio Napoli
Aug 25, 2016·Transplant Immunology·Araminta Guichard-RomeroLuis Eduardo Morales-Buenrostro
Sep 30, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Sophie CaillardAnne Parissiadis
Sep 6, 2014·Journal of Cardiovascular Translational Research·Antonietta PicasciaClaudio Napoli
Jul 2, 2015·Current Opinion in Organ Transplantation·Joong Hyuk Sheen, Peter S Heeger
Dec 8, 2019·Gastroenterología y hepatología·Julien VionnetJordi Colmenero
Jul 29, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Kylie MartinKevin V Chow

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