Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients

The Annals of Pharmacotherapy
Stefan N HartmannOlivier C Meyer

Abstract

Methotrexate and nonsteroidal antiinflammatory drugs are frequently coadministered in the treatment of rheumatoid arthritis (RA). To evaluate the effect of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor, on methotrexate pharmacokinetics and short-term safety in patients with RA. This multicenter, randomized, double-blind, placebo-controlled crossover study enrolled 18 patients (mean age 49.1 y) with stable RA. Patients were randomized to receive methotrexate 7.5-15 mg orally once weekly plus either lumiracoxib 400 mg/day or placebo for 7 days. Patients then received the other treatment combination for an additional 7 days. Serial blood and urine were collected for 24 hours after the methotrexate dose on day 1 (methotrexate alone) and days 8 and 15 (combination treatment). Plasma methotrexate pharmacokinetics (AUC(0-t), maximum concentration [C(max)], time to C(max)) and methotrexate protein binding were similar for methotrexate alone (108.0 ng.h/mL, 26.7 ng/mL, 1.5 h, and 57.1%, respectively), methotrexate/lumiracoxib (110.2 ng.h/mL, 27.5 ng/mL, 1.0 h, and 53.7%, respectively), and methotrexate/placebo (101.8 ng.h/mL, 22.6 ng/mL, 1.0 h, and 57.0%, respectively). Similarly, no clinically significant difference was fou...Continue Reading

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Citations

May 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanjay AnandEdward V Maytin
Nov 14, 2007·European Journal of Clinical Pharmacology·Shaojun Shi, Ulrich Klotz
May 11, 2005·Expert Opinion on Investigational Drugs·Bernard Bannwarth, Francis Berenbaum
Apr 25, 2009·Journal of the American Academy of Dermatology·Robert E KalbMark Lebwohl
Jun 6, 2013·Advances in Pharmacological Sciences·Marinella PatanèEmilio Russo
Jul 31, 2007·Expert Opinion on Pharmacotherapy·Bernard Bannwarth, Francis Bérenbaum
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May 30, 2014·Drug Metabolism and Drug Interactions·Hiroaki HonjoTomohiro Nabekura

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