LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase

European Journal of Medicinal Chemistry
J M CamposA Espinosa

Abstract

Eleven derivatives of 1,1'-[1,2-ethylenebis(benzene-1,4-diylmethylene)]bis(4-pyridinium) dibromides bearing various groups at C-4 of the pyridinium moiety were synthesized and examined for their inhibition of choline kinase (ChoK) and antiproliferative activities. The C-4 substituents include electron-releasing, neutral or electron-withdrawing groups. A one-parameter regression equation has been derived which satisfactorily describes the ex vivo inhibitory potency of ChoK of the title compounds. The electronic effect plays a critical function in the ex vivo inhibition of ChoK although the role of electrostatic interactions could be altered due to a solvation process of both ChoK and ligands.

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Citations

Mar 7, 2003·Il Farmaco·Joaquín CamposAntonio Espinosa
May 2, 2002·Bioorganic & Medicinal Chemistry·Joaquín M CamposA Espinosa
Jul 24, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Gengshu Wu, Dennis E Vance
Apr 14, 2016·Progress in Lipid Research·Sean P ArlauckasE James Delikatny
May 27, 2015·Chemosphere·Yifei SunNobuo Takeda
Apr 16, 2015·Future Medicinal Chemistry·Francisco Fermín Castro-NavasLuisa Carlota López-Cara
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milan MladenovićSlavica Solujić
Feb 13, 2002·Oncogene·Ana Ramírez de MolinaJuan Carlos Lacal
Jul 17, 2014·Molecular Cancer Therapeutics·Sean P ArlauckasEdward J Delikatny
Aug 9, 2003·Journal of Medicinal Chemistry·Ana Conejo-GarcíaAntonio Espinosa
Oct 16, 2004·Journal of Medicinal Chemistry·Ana Conejo-GarcíaJuan Carlos Lacal
Sep 27, 2018·The Journal of Organic Chemistry·Artis KinensEdgars Suna
Jan 17, 2009·Journal of Molecular Graphics & Modelling·P Srivani, G Narahari Sastry

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