Lung accumulation of hyaluronan parallels pulmonary edema in experimental alveolitis.

The American Journal of Physiology
O NettelbladtR Hällgren

Abstract

The glycosaminoglycan hyaluronan (HA, hyaluronate or hyaluronic acid) was quantified in rat lung during the development of bleomycin-induced lung injury. Extracted lung HA was measured by a radiometric assay. In control rats, the HA lung content was 95 +/- 5 (SE) micrograms/g of freeze-dried and homogenized lung tissue. After a single intratracheal instillation of bleomycin, the HA content of the lung increased significantly on day 1. Peak HA concentrations on days 3-7 averaged 70% higher than normal lung HA concentrations. From day 7 the HA concentrations progressively declined and had returned to normal by day 30. Qualitative assessment of lung HA has previously demonstrated that HA is accumulated in the edematous interstitial alveolar space during the alveolitis phase of bleomycin injury. Since high-molecular-weight HA has unique hydrophilic properties, another aim of the study was to elucidate the possible link between the increase in lung HA and the development of interstitial-alveolar edema postbleomycin. HA recovered by bronchoalveolar lavage from bleomycin-injured lungs increased with increasing total lung HA and had a mean molecular size of 220,000 +/- 50,000 (SE), indicating the minimum size of HA accumulated in the a...Continue Reading

Citations

Mar 26, 2005·American Journal of Respiratory and Critical Care Medicine·Kuan-Jen BaiDeborah A Quinn
Dec 18, 2018·Frontiers in Immunology·Pauline JohnsonYifei Dong
Nov 16, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·R E Drake, M F Doursout
Jun 28, 2019·The Tohoku Journal of Experimental Medicine·Goktug SavasMetin Aytekin
Jun 1, 1993·The American Review of Respiratory Disease·P ChanezJ Bousquet
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Gerard M Turino, Jerome O Cantor
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·G MiserocchiG De Luca
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shih-Hsing LeirPeter M Lackie
Jul 1, 1994·Experimental Lung Research·B A BrayG M Turino

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