Lung cancer and intraocular metastasis in gestation: Clinical experiences of a rare case.

Thoracic Cancer
Lin LinJie Wang

Abstract

Lung cancer in pregnancy combined with intraocular metastasis rarely occurs and has a poor prognosis. Here, we report an extremely rare case of a 31-year-old non-smoking pregnant female who was diagnosed with lung adenocarcinoma with multiple metastasis including choroidal metastasis. Whole exon sequencing was performed but no appropriate therapeutic target was identified. The patient received standard pemetrexed plus carboplatin for first-line treatment after delivery. Ophthalmic treatment including transpupillary thermotherapy and intravitreal ranibizumab injections were administered and the patient responded very well to treatment. Her visual acuity was restored, indicating systemic therapy combined with ophthalmic treatment was an appropriate choice of therapy. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: The case reported here of a pregnant female diagnosed with lung cancer with choroidal metastasis highlights the aggressive characteristics of the disease. WHAT THIS STUDY ADDS: Systemic therapy in combination with ocular therapy is an appropriate choice of treatment.

References

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May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Oct 31, 2013·The British Journal of Ophthalmology·Lazaros KonstantinidisBertil Damato
Feb 24, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xiaoli MaUNKNOWN LACE-Bio Collaborative Group
Jul 14, 2016·Journal of Advanced Research·Sotirios MitrouNicholas Pavlidis
Apr 12, 2017·Asia-Pacific Journal of Ophthalmology·Lazaros Konstantinidis, Bertil Damato

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