PMID: 11901918Mar 21, 2002Paper

Lung cancer evolution to preinvasive management

Clinics in Chest Medicine
J L MulshineLuigi M De Luca

Abstract

Cancer screening measures generally are accepted for cervical, breast, and colon cancer. With prostate cancer screening, the practice is used broadly, but the evidence for this approach is not established clearly. The aggregate clinical experience with these screening procedures provides a useful precedent to consider in designing a new approach to lung cancer screening. For instance, formidable logistic issues exist in responsibly evaluating the vast at-risk population for lung cancer. Obvious issues include the needs for cost-economy and precise classification procedures. In the field of cervical cancer screening, recent developments in automated image analysis highlight the potential for improving the precision of diagnosis by moving beyond traditional manual cytomorphologic evaluation. The authors have outlined how the overexpression of hnRNP A2/B1 was associated significantly with the eventual development of lung cancer, as corroborated by several independent studies. In discussing this marker, they reviewed several issues with relevance to the general challenge in using biomarkers as screening tools for lung cancer. The experience with cervical cancer screening informs the development of a cellular diagnostic screening pl...Continue Reading

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Citations

Apr 18, 2003·Seminars in Roentgenology·Robert Clark
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J L MulshineF Cuttitta
Jan 16, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Dandan Yi, Timothy Scott Wiedmann
Nov 28, 2002·Thorax·J L Mulshine, R A Smith
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Jul 15, 2005·Journal of Cell Science·Yaowu HeRoss Smith

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