[Lung cancer from the perspective of internal medicine and surgery].

Der Radiologe
A PrasseJ Müller-Quernheim

Abstract

In previous years numerous advances in diagnostics, staging and therapy of lung cancer have been achieved. Nevertheless, it remains the most frequent cause of death from cancerous diseases. Early diagnosis and exact staging enable multimodal therapy regimens adjusted to age and comorbidities, which result in complete remission in a few and in prolonged survival and good quality of life in most patients. Curative surgery is possible in stage I non-small cell lung cancer (NSCLC) and results in a 5-year survival rates of up to approximately 75%. Using multimodal therapy approaches long-term survival can even be achieved in 40-50% of patients with advanced T4 tumors. However, in NSCLC with distant metastases median survival time is only 8-12 months. In elderly patients with no surgical options low cytotoxic monotherapy can be employed with a palliative intent. In the limited disease stage of small cell lung cancer (SCLC) long lasting remission after polychemotherapy has been observed in a minority of patients. However, in the extensive disease stage polychemotherapy prolongs the survival time of SCLC patients from 1-2 months to approximately 12 months.

References

Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Mar 29, 2007·Respiration; International Review of Thoracic Diseases·Yoshihiro KobashiMikio Oka
Oct 6, 2007·Chest·M Patricia RiveraUNKNOWN American College of Chest Physicians
Oct 6, 2007·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Feb 12, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wulf SienelBernward Passlick
Jun 28, 2008·The Lancet Oncology·Michael ThomasUNKNOWN German Lung Cancer Cooperative Group
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tristan D YanBrian C McCaughan
Jul 2, 2009·The European Respiratory Journal·A BrunelliUNKNOWN European Respiratory Society and European Society of Thoracic Surgeons joint task force on fitness for radical therapy
Jul 22, 2009·Archives of Otolaryngology--head & Neck Surgery·Tawee TanvetyanonAndy Trotti
Aug 19, 2009·BMJ : British Medical Journal·Gerard A SilvestriJames Ravenel
Aug 21, 2009·The New England Journal of Medicine·Tony S MokMasahiro Fukuoka
Mar 23, 2010·Pneumologie·G GoeckenjanUNKNOWN Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin und die Deutsche Krebsgesellschaft

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Citations

Jan 22, 2011·Der Radiologe·C HintzeM Puderbach

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