Lung cancer in never-smokers - what are the differences?

Acta Oncologica
Margarida DiasAna Barroso

Abstract

Characteristics of never-smokers with lung cancer are still not fully clarified. The aim of this study was to compare never-smokers and ever-smokers with non-small cell lung cancer (NSCLC) regarding patient and tumor characteristics. All consecutive newly NSCLC patients with known smoking status diagnosed between 2011 and 2015 were included in this retrospective cohort study. Clinical, histological, and molecular characteristics were compared between ever-smokers and never-smokers. Of the 558 included patients, 125 (22.4%) were never-smokers. These patients were more likely to be female (74% vs. 7%, p < .001), older (67 vs. 66 years-old, p = .019), and have adenocarcinoma (93% vs. 65%, p < .001). Never-smokers took longer to seek medical care after the symptoms onset (3 vs. 2 months, p < .001), regardless of the symptoms, histological type, or gender (OR: 1.2 [1.4-2.0]). The metastatic pattern was different in never-smokers: pleural metastases were more frequent (OR: 2.1 [1.1-4.0]), regardless of the histological type and gender. Never-smokers had a higher prevalence of ALK translocations (26% vs. 4%, p < .001) and EGFR mutations (36% vs. 8%, p < .001). The type of EGFR mutation was also significantly different between groups. ...Continue Reading

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Citations

Sep 15, 2017·The Clinical Respiratory Journal·Ildikó Fritz, Håkan Olsson
Sep 14, 2018·American Journal of Clinical Oncology·Amanda J W GibsonWinson Y Cheung
Jun 22, 2020·Journal of Applied Genetics·Raneem Y HammouzAndrzej K Bednarek
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Oct 12, 2018·Tuberculosis and Respiratory Diseases·Young Chul Kim, Young Joo Won
Apr 17, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dyda DaoJennifer G Le-Rademacher
Feb 5, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Elvin S ChengXue Qin Yu
May 20, 2021·Computational and Mathematical Methods in Medicine·Ziyuan ShenShuiping Huang

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