Lung cancer incidence in patients with schizophrenia: meta-analysis

The British Journal of Psychiatry : the Journal of Mental Science
Chuanjun ZhuoPatrick Todd Triplett

Abstract

Lung cancer risk factors, like tobacco smoking, are highly prevalent in patients with schizophrenia. Whether these patients have a higher risk of lung cancer remains unknown. We aimed to investigate whether patients with schizophrenia have a higher incidence of lung cancer compared with general population, in a meta-analysis. Eligible studies were searched from PubMed and EMBASE databases to identify cases of lung cancer in patients with schizophrenia and the general population. This meta-analysis utilised the random-effects model and prediction interval was used to calculate the heterogeneity of these eligible studies. We assessed the quality of evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. There were 12 studies, totalling 496 265 patients, included in this meta-analysis. The data showed that the baseline schizophrenia diagnosis was not associated with any changes in lung cancer incidence in the overall population, with a standardised incidence ratio of 1.11 (95% CI 0.90-1.37; P = 0.31), although there was a significant heterogeneity among these studies (I2 = 94%). Moreover, there was also a substantial between-study variance with wide prediction interval values (0.47-2.6...Continue Reading

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Citations

Sep 12, 2020·Psycho-oncology·Luigi Grassi, Michelle Riba
Sep 10, 2020·Evidence-based Mental Health·Samuele CorteseChristoph Correll
Feb 19, 2021·Journal of Psychiatric Research·Paolo GirardiFrancesco Amaddeo
Feb 10, 2021·Current Opinion in Psychiatry·Merete NordentoftThomas Munk Laursen

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