Lung cancer neovascularisation: Cellular and molecular interaction between endothelial and lung cancer cells

Immunobiology
Sabine KaessmeyerJohanna Plendl

Abstract

Novel vascular-independent conduits have been observed in some cancers. These have been variously described as vasculogenic mimicry, mosaic vessel formation, vascular co-option and intratumour embryonic-like vasculogenesis. Despite lung cancer being the most common cancer worldwide, there is little information on its neovascularisation or the pathways involved. An in vitro model involving co-cultures of microvascular lung endothelial cells and squamous or adenocarcinoma lung cancer cells was developed to assess their angiogenic interaction. Cells were incubated and examined by phase contrast microscopy and by immunocytochemistry in both mono- and co-cultures. Cultured cells and lung cancer tissue sections were assessed for new tumour vessel formation, expression of the endothelial marker CD31 and morphology. Lung tumour cells and endothelial cells interacted morphologically via pseudopodia and used alternative pathways to generate new vessels. Co-culturing microvascular endothelial and squamous carcinoma cells led to endothelial cells surrounding tumour cells and the tumour cells being incorporated into vessel walls. Co-culturing endothelial and adenocarcinoma cells resulted in cellular contact and the formation of tumour cell ...Continue Reading

References

Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·S A NicholsonP E Swanson
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y S ChangL L Munn
Sep 22, 2001·Bulletin of Mathematical Biology·H A LevineM Nilsen-Hamilton
Jan 1, 2003·Clinical Chemistry·Robert AuerbachNasim Akhtar
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Robert Folberg, Andrew J Maniotis
Mar 21, 2006·Journal of Theoretical Biology·K Bartha, H Rieger
Sep 12, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F BachD Burke
Nov 3, 2006·American Journal of Respiratory Cell and Molecular Biology·Marc R McClellandDouglas A Arenberg
Aug 25, 2007·Cancer Metastasis Reviews·Femke Hillen, Arjan W Griffioen
Nov 6, 2008·Anatomia, histologia, embryologia·S KässmeyerM Bahramsoltani
Jan 23, 2009·Immunobiology·Laura RidolfiRuggero Ridolfi
Feb 13, 2009·Angiogenesis·Susana F Rocha, Ralf H Adams
Mar 31, 2009·Clinical & Experimental Metastasis·Khair ElzarradAbu-Bakr Al-Mehdi
Aug 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Isaac P Witz
Dec 17, 2010·World Journal of Gastrointestinal Surgery·Yue-Zu Fan, Wei Sun
Mar 10, 2011·Nature Medicine·Hans Clevers
Jun 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benedetta BussolatiGiovanni Camussi
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Merel KimmanMark Woodward
Jun 29, 2012·Journal of Vascular Research·Ward De SpiegelaerePieter Cornillie

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Citations

Aug 13, 2015·International Journal of Molecular Sciences·Lisha QiBaocun Sun
Dec 31, 2015·Medical Oncology·Jiatao LiuGuoping Sun
Nov 9, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Xin LuoGuanghua Xiao
Mar 23, 2017·Molecular Cancer·Daniel Delgado-BellidoF Javier Oliver
Feb 7, 2015·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·William H MárquezJaime A Gallo
Apr 25, 2015·Oncotarget·He MaZhengnian Ding
May 3, 2018·Journal of Experimental & Clinical Cancer Research : CR·Concetta SaponaroAnita Mangia
Feb 18, 2021·Environmental Science and Pollution Research International·Madhuri GroverDhruv Setia
Dec 31, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yukako YagiWilliam D Travis

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