PMID: 3759459Oct 1, 1986Paper

Lung cancer risk at low doses of alpha particles

Health Physics
W HofmannC X Zhang

Abstract

A survey of inhabitant exposures arising from the inhalation of 222Rn and 220Rn progeny, and lung cancer mortality has been carried out in two adjacent areas in Guangdong Province, People's Republic of China, designated as the "high background" and the "control" area. Annual exposure rates are 0.38 working level months (WLM) per year in the high background, and 0.16 WLM/yr in the control area. In 14 yr of continuous study, from 1970 to 1983, age-adjusted mortality rates were found to be 2.7 per 10(5) living persons of all ages in the high background area, and 2.9 per 10(5) living persons in the control area. From this data, we conclude that we are unable to determine excess lung cancers over the normal fluctuations below a cumulative exposure of 15 WLM. This conclusion is supported by lung cancer mortality data from Austrian and Finnish high-background areas. A theoretical analysis of epidemiological data on human lung cancer incidence from inhaled 222Rn and 220Rn progeny, which takes into account cell killing as competitive with malignant transformation, leads to the evaluation of a risk factor which is either a linear-exponential or a quadratic-exponential function of the alpha-particle dose. Animal lung cancer data and theor...Continue Reading

Citations

Sep 1, 1992·Il Nuovo Cimento Della Società Italiana Di Fisica. C·C Signorini, A M Conforto
Aug 1, 1988·The Science of the Total Environment·A K Haque, I A Al-Affan
Sep 6, 2003·Journal of Environmental Radioactivity·Lene H S VeigaEliana C S Amaral
Mar 6, 2008·Radiation Protection Dosimetry·V Zareena HamzaMary N Mohankumar
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R Latarjet, M Tubiana
Apr 9, 1992·Nature·S P Wolff
Nov 20, 2016·Microscopy Research and Technique·Magdalena KaczmarskaKvětoslava Burda
Dec 22, 2019·Radiation and Environmental Biophysics·Werner HofmannImre Balásházy

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